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Old 12-07-2006, 01:35 PM   #2
heblaj01
Senior Member
 
Join Date: Apr 2006
Posts: 543
Donna,

In an other thread (http://www.her2support.org/vbulletin...light=orlistat) Lani pointed out that Xenical (Orlistat) is not aborbed by the digestive system so that its anticancer properties observed in lab conditions could only happen in humans if it was injected (intravenous or intramuscular) not when it is taken orally. I don't know if I.V. injection was ever tried.
An other point is that since your are taking a number of fatty acids if you were to add Xenical at the same time it could reduce their absorption by about 30% based on the fact that Xenical inhbits the lipase ezyme required to help fat absorption in the gut. So fatty acid dose compensation would be required to maintain the same effectiveness. This might worsen one side effect of Xenical: loose stools
Dose compensation might also be required for fat soluble vitamins normally provided by diet such as vitamin B,D,E,K.
One potential benefit of oral intake of Orlistat in cancer is in reduction of obesity which is a risk factor for several types of cancer.
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