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Hi Cindy, I've been having difficulty deciding if I prefer the side effects of tamox (uterine cancer) vs the side effects of AI (osteoporosis). We are all individuals so what is true for one may not hold for all.
I'm 47, IIB, HER2, ER and PR+. Tamox has been around awhile and is effective in lowering recurrence rate. There are some studies that show switching to an AI after 2 years on tamox show even greater efficacy on preventing recurrence. You have reached this 2 year threshold. AI's will not work at all if your estradiol levels still show you to be premenopausal. That leaves you with the choice of Lupron shots + AI or oophrectomy. There are some studies that show using AI's from the get go are superior, if you are post meno.
As far as tamoxifen resistance, I think that was most pronounced in PR negs but can't say for sure.
I've been on tamox for 9 mos. It's easy. We've kicked around switching but there's been no hard push.
None of the studies are exactly tailored to you. If I were you I would closely look at results published between now and June and make a decision in June. That's what I'll be doing. Good luck, BB
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