Carol,
Follow the indications given above by Joe for your main concern, the brain mets.
Regarding bone mets, if Pamidronate stops helping you, do not forget that Zometa is likely to be still effective (& perhaps more effective) as demonstrated in this study:
http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum
If you do switch to Zometa at some time in the future, I suggest you request the infusion time to be extended from 15 to 30 minutes to reduce further the small risk of kidney problems which are slightly more frequent when Zometa is given after Pamidronate