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mkrny · 11-22-2006, 08:47 AM

All,
Thanks for the words of support.

Lolly,
Yes herceptin injected into the cerebral spinal fluid (CSF) either via lumbar puncture (ouch) or Ommaya reservior (port through skull). Genetech's standard formula must be changed though. Our neuro-onc is trying to get Genetech to reformulate it and back a clinical trial for IT use or at least endorse IT use. Right now they aren't too interested. As our neuro-onc explained Genetech delivers the drug in a box with two jars, one with powder (the drug) and the other is water with something in it that will kill patient if used IT. So they open the box and throw out the water and reformulate it at their pharmacy using the receipe from the European study.

Maybe Joe can work on them Genetech his side.

heblaj01,
Thanks for the references,
1- I'll discuss the RTA744 trial w/ oncs, I haven't seen that before
2- I've discussed the Boswellia Serrata with our neuro-onc (he came from Sloan but didn't work w/ it there so he didn't have too much to say about it). I'll need to look into that more.
3- Unfortunately the current guidelines for brain mets doesn't cover leptomenengeal decease.

Thanks again,

11-22-2006, 08:47 AM	#6
mkrny Senior Member Join Date: Mar 2006 Location: LI, NY Posts: 38	IT=intrathecal All, Thanks for the words of support. Lolly, Yes herceptin injected into the cerebral spinal fluid (CSF) either via lumbar puncture (ouch) or Ommaya reservior (port through skull). Genetech's standard formula must be changed though. Our neuro-onc is trying to get Genetech to reformulate it and back a clinical trial for IT use or at least endorse IT use. Right now they aren't too interested. As our neuro-onc explained Genetech delivers the drug in a box with two jars, one with powder (the drug) and the other is water with something in it that will kill patient if used IT. So they open the box and throw out the water and reformulate it at their pharmacy using the receipe from the European study. Maybe Joe can work on them Genetech his side. heblaj01, Thanks for the references, 1- I'll discuss the RTA744 trial w/ oncs, I haven't seen that before 2- I've discussed the Boswellia Serrata with our neuro-onc (he came from Sloan but didn't work w/ it there so he didn't have too much to say about it). I'll need to look into that more. 3- Unfortunately the current guidelines for brain mets doesn't cover leptomenengeal decease. Thanks again, __________________ Maryann & Ken __________________ Stage IV, Her2/Neu 3+++, Er & Pr positive, Primary mets to brain/CSF, bones & lymphs DX: 2/01, DCIS Rt one, Neoadjuvant chemo, MRM 7/01 Rads to chest, neck, lower spine, pelvis WBR & cyberknife Numerous chemo/hormonal cocktails along the way 10/11/06: Started Trial of Lapatinib/Xeloda, after 2 cycles it is declared a failure for us. 11/24/06: Now starting rads to upper spine then IT herceptin 12/07: Took a turn for the worse and entered hospice. Enjoyed remaining time with family and friends feasting on cookies and sushi. 4/11/07: Peacefully passed on. Maryann will be missed by all.