HER2 Support Group Forums - View Single Post - what is your risk of brain metastases and what are they recommending you do about it?

Lani · 11-15-2006, 09:28 AM

i just went over the original article--yes her2+ breast cancer patients have a proclivity to metastasize to the brain

Only 30 of the her2+ early breast cancer patients in this study got herceptin as part of a clinical trial, so it was not herceptin which was affecting where the mets presented or didn't present in the majority of cases (some say herceptin is changing the natural history of the disease by preventing most of the liver, bone and lung mets but being unable to prevent the brain mets due to its inability to cross the blood-brain barrier)

Of the her2+ patients who developed brain mets, it seems more were ER- than ER+

Hope this helps!

11-15-2006, 09:28 AM	#3
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	Kelly i just went over the original article--yes her2+ breast cancer patients have a proclivity to metastasize to the brain Only 30 of the her2+ early breast cancer patients in this study got herceptin as part of a clinical trial, so it was not herceptin which was affecting where the mets presented or didn't present in the majority of cases (some say herceptin is changing the natural history of the disease by preventing most of the liver, bone and lung mets but being unable to prevent the brain mets due to its inability to cross the blood-brain barrier) Of the her2+ patients who developed brain mets, it seems more were ER- than ER+ Hope this helps!