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Lani · 10-18-2006, 06:31 PM

egorization of breast cancer, it includes all ER+her2+ breast cancers and some others ie, all strongly ER+her2+ bc falls in this category. I will work on reading the original article to understand this 2% categorization better if I can.
From what I understand her2neu is on chromosome 17...this article is the first I read on chromosome 16.
The other article is hot-off-the press today as wel is fascinating and has to do with chromosome 17. It is by Martine Piccart , the head of all the HERA trials, among others and is on how best to test for those her2+ patients who will most likely respond to herceptin ie, IHC vs FISH correcting for an aberrancy of chromosome 17 which creates a false positive. It concluded that those whose FISH was >6 did not suffer from this aberrancy which could create the false impression of her2 overexpression.

As I remain crummy at adding things to posts without losing them, I will add the reference as my next reply to this thread.

10-18-2006, 06:31 PM	#78
Lani Senior Member Join Date: Mar 2006 Posts: 4,782	from what I understand from Charles Perou, one of the pioneers of this molecular cat- egorization of breast cancer, it includes all ER+her2+ breast cancers and some others ie, all strongly ER+her2+ bc falls in this category. I will work on reading the original article to understand this 2% categorization better if I can. From what I understand her2neu is on chromosome 17...this article is the first I read on chromosome 16. The other article is hot-off-the press today as wel is fascinating and has to do with chromosome 17. It is by Martine Piccart , the head of all the HERA trials, among others and is on how best to test for those her2+ patients who will most likely respond to herceptin ie, IHC vs FISH correcting for an aberrancy of chromosome 17 which creates a false positive. It concluded that those whose FISH was >6 did not suffer from this aberrancy which could create the false impression of her2 overexpression. As I remain crummy at adding things to posts without losing them, I will add the reference as my next reply to this thread.