HER2 Support Group Forums - View Single Post - season of diagnosis and treatment start of brst cancer influences result!!

Lani · 10-11-2006, 06:22 AM

I believe that is why they listed not just the season of diagnosis but also the season of initiation of treatment (besides the fact that Denmark is shamefully slow in getting newly diagnosed patients in for treatment!)

Studies have shown that the number of months before peaks of recurrence (around 24 for her2+bc, later and with two peaks for her2- bc) start being counted only from the date of surgery, not the date the tumor was discovered. In those who procrastinated treatment, or where other factors intervened, the "clock" started ticking only after the time of surgery. That, plus the fact that the genetic signature of breast cancer is similar to the genetic signature of inflammation and wound healing have made scientists propose that the surgery starts the clock ticking by initiating an inflammatory reaction.

Perhaps a dose of antiinflammatory medication without anticlotting potential and an antiangiogenic drug given just before surgery and anaesthetic block at the time of surgery could decrease this inflammatory response.

Just thoughts!

10-11-2006, 06:22 AM	#5
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	the "clock" starts ticking only when surgery performed, not when tumor discovered! I believe that is why they listed not just the season of diagnosis but also the season of initiation of treatment (besides the fact that Denmark is shamefully slow in getting newly diagnosed patients in for treatment!) Studies have shown that the number of months before peaks of recurrence (around 24 for her2+bc, later and with two peaks for her2- bc) start being counted only from the date of surgery, not the date the tumor was discovered. In those who procrastinated treatment, or where other factors intervened, the "clock" started ticking only after the time of surgery. That, plus the fact that the genetic signature of breast cancer is similar to the genetic signature of inflammation and wound healing have made scientists propose that the surgery starts the clock ticking by initiating an inflammatory reaction. Perhaps a dose of antiinflammatory medication without anticlotting potential and an antiangiogenic drug given just before surgery and anaesthetic block at the time of surgery could decrease this inflammatory response. Just thoughts!