HER2 Support Group Forums - View Single Post - the (or one of the) REASON WHY smaller is better in breast cancer!

Lani · 10-03-2006, 02:24 PM

in your tumor...if you don't, the cells don't stick to each other and break off easily and migrate into the bloodstream and lymphatic system and float off to distant areas to take root as metastases.

They knew that her2+ breast cancer metastasized more easily/widely than other types of breast cancer, particularly plain old her2-ER+---but this also shows that there is some aspect/signal produced when a tumor gets beyond a certain size which allows less of the proteins hence more possibilities for metastases to form when cells break loose.

SO a smaller her2+ breast cancer is better than a larger one, but a her2- breast cancer (at least if not triple negative) is generally speaking less likely to metastasize or do so widely than a her2+ one.

10-03-2006, 02:24 PM	#4
Lani Senior Member Join Date: Mar 2006 Posts: 4,783	YOU WANT to have adhesion proteins in your tumor...if you don't, the cells don't stick to each other and break off easily and migrate into the bloodstream and lymphatic system and float off to distant areas to take root as metastases. They knew that her2+ breast cancer metastasized more easily/widely than other types of breast cancer, particularly plain old her2-ER+---but this also shows that there is some aspect/signal produced when a tumor gets beyond a certain size which allows less of the proteins hence more possibilities for metastases to form when cells break loose. SO a smaller her2+ breast cancer is better than a larger one, but a her2- breast cancer (at least if not triple negative) is generally speaking less likely to metastasize or do so widely than a her2+ one.