[RobinP]

Dianaq I wish you good luck with your clinical study on Herceptin without chemo. I think we need to know more about how Herceptin without chemo works in the adjuvant study so I thank you for your participation. Certainly, chemo is not the answer for everyone for various reasons.

To me, Herceptin is what is really changing the ball game for Her2 positives. Nothing else has increased survival like it in the adjuvant setting. Even when H. was used later, after chemo in the HERA study, it was still very effective at decreasing relapse. So I don’t see why it still would not be effective alone, without chemo. In fact, in the HERA trial many kinds of chemotherapy were used with and without Taxol, but the Herceptin study group still faired much better than the controls NOT on Herceptin. Further, Becky reported from the 2006ASCO that use of late H., far as three years out from treatment, was having early signs of H. benefit. To me, that says a lot to support your clinical study.



The only thing I would suggest is that you test your tumor for TOPAII since this is the one case that I would strongly recommend AC chemo for her2+. Take care.