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heblaj01 · 09-06-2006, 09:32 AM

In this article Milk Thisle is shown not to inhibit Human Cytochrome P450 3A.
I am not knowledgeable in biochemistry:
does it follow that Milk Thisle (& its components Silymarin & Silybinin) is not likely to interfere with chemo drugs which use Cytochrome P450 3A for their metabolism?
Any opinion?

http://jcp.sagepub.com/cgi/content/abstract/46/2/201
Assessing the Clinical Significance of Botanical Supplementation on Human Cytochrome P450 3A Activity: Comparison of a Milk Thistle and Black Cohosh Product to Rifampin and Clarithromycin

P.S.
I have read that Silybinin is the main if not the only active ingredient in Milk Thisle for liver supplementation & furthermore that the Silybinin Phytosome version is better for bioavailability.
Anyone agrees or disagrees?

09-06-2006, 09:32 AM	#8
heblaj01 Senior Member Join Date: Apr 2006 Posts: 543	Milk Thisle & Human Cytochrome P450 3A In this article Milk Thisle is shown not to inhibit Human Cytochrome P450 3A. I am not knowledgeable in biochemistry: does it follow that Milk Thisle (& its components Silymarin & Silybinin) is not likely to interfere with chemo drugs which use Cytochrome P450 3A for their metabolism? Any opinion? http://jcp.sagepub.com/cgi/content/abstract/46/2/201 Assessing the Clinical Significance of Botanical Supplementation on Human Cytochrome P450 3A Activity: Comparison of a Milk Thistle and Black Cohosh Product to Rifampin and Clarithromycin P.S. I have read that Silybinin is the main if not the only active ingredient in Milk Thisle for liver supplementation & furthermore that the Silybinin Phytosome version is better for bioavailability. Anyone agrees or disagrees?