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pattyz · 08-27-2006, 05:17 PM

Emmay,

As far as I know, I'm the only one currently (most recently atleast) using the combo of Temodar and Xeloda for my eight brain mets. Since I am on this combination, truely I don't know which has worked...

After the first two rounds (250mg Temodar x 7das plus 2000mg total Xeloda x 14 das - two weeks off) MRi showed shrinkage of nearly 50%. After the next two rounds, Mri showed identical results.

By the third & fourth rounds Mri's showed all stable no new lesions.

I went on a chemo break for four months. By the Mri at end of that Mri was read as: minimal increase in size of two of the eight mets. The balance remain stable.

Back on chemo, with a glitch. Was twice denied the Temodar so did Xeloda alone. Next Mri not until the end of Sept. and am still trying to get back the Temodar.

My counts would drop with the Temodar but come back during week of Xeloda alone. The anti-nausea meds along with the Temodar complicate my chronic constipation. It is vital to take an anti-nausea med, trust me on that.

That is all I can report as side effects.

I have been nearly asymptomatic from my brain mets. Yet, just before I began my first round of T&X, I became dizzy 24/7 with falling over events. After less than a full week on my chemos, I felt less dizzy. By the full week the dizziness was really gone. I feel very lucky to have responded so well to these two drugs. Makes my onc a happy camper too, as it was by my encouragement we tried this.

I've had five seperate focalized sessions of radiation to treat 16 other brain mets. Three SRS and two CyberKnife. No whole brain radiation, no surgeries.

I am also NED in body after responding to Navelbine/Herceptin in Nov. '02.

All I can say is: give it a try. The small study done showed a few gals that had a partial response with just one having complete response. I figure it can be any one of us in that small group, too.

sorry to go on....
hope that answered your questions,
best to you and your sister,
pattyz

08-27-2006, 05:17 PM	#3
pattyz Senior Member Join Date: Mar 2006 Posts: 306	Emmay, As far as I know, I'm the only one currently (most recently atleast) using the combo of Temodar and Xeloda for my eight brain mets. Since I am on this combination, truely I don't know which has worked... After the first two rounds (250mg Temodar x 7das plus 2000mg total Xeloda x 14 das - two weeks off) MRi showed shrinkage of nearly 50%. After the next two rounds, Mri showed identical results. By the third & fourth rounds Mri's showed all stable no new lesions. I went on a chemo break for four months. By the Mri at end of that Mri was read as: minimal increase in size of two of the eight mets. The balance remain stable. Back on chemo, with a glitch. Was twice denied the Temodar so did Xeloda alone. Next Mri not until the end of Sept. and am still trying to get back the Temodar. My counts would drop with the Temodar but come back during week of Xeloda alone. The anti-nausea meds along with the Temodar complicate my chronic constipation. It is vital to take an anti-nausea med, trust me on that. That is all I can report as side effects. I have been nearly asymptomatic from my brain mets. Yet, just before I began my first round of T&X, I became dizzy 24/7 with falling over events. After less than a full week on my chemos, I felt less dizzy. By the full week the dizziness was really gone. I feel very lucky to have responded so well to these two drugs. Makes my onc a happy camper too, as it was by my encouragement we tried this. I've had five seperate focalized sessions of radiation to treat 16 other brain mets. Three SRS and two CyberKnife. No whole brain radiation, no surgeries. I am also NED in body after responding to Navelbine/Herceptin in Nov. '02. All I can say is: give it a try. The small study done showed a few gals that had a partial response with just one having complete response. I figure it can be any one of us in that small group, too. sorry to go on.... hope that answered your questions, best to you and your sister, pattyz Last edited by pattyz; 08-27-2006 at 05:20 PM..