As far as I know there is no foolproof marker of efficacy currently available for antiestrogen drug treatments.In addition, since these drugs are slow acting (in comparison with chemo) signs of efficacy take a long time to show up which is not helpfull when the treatment is not working from the begining or is starting to fail.
However there is hope that a very accurate & very early diagnostic tool of efficacy may be in the works based on this initial small scale study:
Nuclear Medicine Imaging Allows Prediction Of Breast Cancer Patients' Response To Hormonal Treatment
http://www.sciencedaily.com/release...60119231641.htm
If this pans out, months of useless treatments may be avoided in the case of non responders to hormonal therapy.