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Search: Posts Made By: donocco
Forum: Clinical Trials 01-06-2014, 05:27 PM
Replies: 9
Views: 13,893
Posted By donocco
Re: Tivatinib (ARQ-197)

Elizabeth

If you think of it like the alphabet it becomes less formidble. To say P13K to AKT to MTor is just like saying A B C.

Your idea of a P13K inhibitor makes a lot of sense. There is...
Forum: Clinical Trials 01-05-2014, 07:01 PM
Replies: 9
Views: 13,893
Posted By donocco
Re: Tivatinib (ARQ-197)

Elizabeth

Since you are interested in this Ill show you how complicated it gets. Affinitor is an anticancer drug that inhibits M-Tor. There are two froms of M-Tor and Affinitor mostly inhibits...
Forum: Clinical Trials 01-05-2014, 04:11 PM
Replies: 9
Views: 13,893
Posted By donocco
Re: Tivatinib (ARQ-197)

I read the article on C-MET and learned a lot. I dont know if it would make sense putting it on the board. Its sort of an A-B-C-D-E-F thing, A being C-met which is connected to another protein (B)...
Forum: Clinical Trials 01-03-2014, 10:59 PM
Replies: 9
Views: 13,893
Posted By donocco
Re: Tivatinib (ARQ-197)

Ill do some research on it. What i put down was very preliminary. I sent an article on the Hepatocyte Growth factor to my wife's computer at work and Ill read it tonight. Tivatinib or ARK-197...
Forum: Clinical Trials 01-03-2014, 12:23 AM
Replies: 9
Views: 13,893
Posted By donocco
Re: Tivatinib (ARQ-197)

I found another article I xeroxed from the Pharmacy I last worked at about ARQ-197 (Tivatinib).

For one thing there were some prolonged stablization of disease when ARQ-197 was given in...
Forum: Clinical Trials 01-02-2014, 11:46 PM
Replies: 9
Views: 13,893
Posted By donocco
Tivatinib (ARQ-197)

I dont know if this investigational drug has been mentioned before. It is an inhibitor of C-MET which is the Hepatocyte Growth Factor Tyrosine Kinase. Apparently C-Met is overactive in various...
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