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Forum: her2group 07-20-2016, 09:51 AM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

bump -- I should update it
Forum: her2group 02-19-2016, 10:08 AM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

This one is a little older so it is a little dated. What I liked about it is the explanation of active versus passive immunotherapy strategies and also understanding why melanoma is being pursued as...
Forum: her2group 02-19-2016, 10:01 AM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

"
Results from a phase 1b "basket" (multidisease cohort) trial of pembrolizumab (Keytruda, Merck) for patients with advanced solid tumors expressing the programmed death 1 ligand (PD-L1) show that...
Forum: her2group 02-17-2016, 11:37 PM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

Some of the immunotherapies are targeting hormonally positive BC patients at risk for having their cancer mutate to HER2+. I read somewhere, and this isn't exclusively true, that having a low PR...
Forum: her2group 02-16-2016, 09:46 AM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

"The immunotherapeutic AE37 is designed to work indirectly by stimulating the patient's immune system to recognize and kill cancer cells. An advantage of AE37 is that it potently activates a...
Forum: her2group 01-26-2016, 11:50 PM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

A good list of cancer immunotherapy drugs based on clinical trials (no date observed)...
Forum: her2group 01-18-2016, 09:32 AM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

I wish. Those of us unlucky enough to be stage 3-4 have easier access unfortunately and you are correct in your assumption that you need to try these drugs sooner rather than later.

I honestly...
Forum: her2group 01-15-2016, 03:57 PM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

Summary of articles about PD-1 (Keytruda):

http://www.fiercebiotech.com/tags/pd-1
Forum: her2group 12-11-2015, 11:32 AM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

This is the reality, and part of the ad campaign running in Seattle that my friend was griping about.
...
Forum: her2group 12-04-2015, 08:09 AM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

Cancer cells exploit the PD-1 pathway to create an immunosuppressive environment. There is often an increase in the production of inhibitory pathways and suppression of stimulatory pathways, allowing...
Forum: her2group 11-22-2015, 06:15 PM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

This link should bring up HER2 immunotherapy trials on the Translational Medicine website:

http://www.translational-medicine.com/search/results?terms=HER2%20immunotherapy
Forum: her2group 11-16-2015, 07:11 AM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

A little out there for the topic but has some of the most detailed explanations I've found about what makes HER2+ cancers. They are looking for immunotherapies that can be given when the tumor burden...
Forum: her2group 11-11-2015, 02:41 PM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

I got the sense from speaking with someone from the University of Washington Tumor Vaccine Group that more breast cancer immunotherapy trials would be going on if there was more funding. I don't know...
Forum: her2group 10-31-2015, 08:21 AM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

This page has a great overview of the different immunotherapy agents being studied for breast cancer

http://www.cancerresearch.org/cancer-immunotherapy/impacting-all-cancers/breast-cancer
Forum: her2group 10-31-2015, 08:20 AM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

Here is a great link to pull up a current breast cancer immunotherapy trials. Some are for HER2, some stage 4. Take a look.
...
Forum: her2group 10-18-2015, 07:56 AM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

Persistent immunity and survival after immunization with a HER2/neu (HER2) vaccine. (2009)
http://meetinglibrary.asco.org/content/35603-65

Results: Median follow-up time for the 21 patients still...
Forum: her2group 10-06-2015, 02:56 AM
Replies: 27
Views: 17,142
Posted By agness
Re: HER2 and Immunotherapy Studies for reference

HER2-specific T cells As An Immunotherapy In HER2-Positive Sarcoma (2015)
http://immuno-oncologynews.com/2015/03/31/her2-specific-t-cells-as-an-immunotherapy-in-her2-positive-sarcoma/


Dr....
Forum: her2group 10-06-2015, 02:52 AM
Replies: 27
Views: 17,142
Posted By agness
Arrow HER2 and Immunotherapy Studies for reference

Novel Vaccine Decreases Recurrence in HER2 Positive Breast Cancer Patients
http://immuno-oncologynews.com/2014/09/08/novel-vaccine-decreases-recurrence-her2-positive-breast-cancer-patients/

The...
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