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Search: Posts Made By: schoonder
Forum: General Cancer News 06-02-2018, 09:24 AM
Replies: 1
Views: 928
Posted By schoonder
Re: Phase I trial shows safety of investigational drug in treating chronic lymphocyti

at asco:
https://meetinglibrary.asco.org/record/161802/abstract
Authors:
Tejal Amar Patel, Joe Ensor, Angel Augusto Rodriguez, Anna Belcheva, Jorge German Darcourt, Polly Ann Niravath, John G....
Forum: her2group 11-01-2016, 07:39 AM
Replies: 13
Views: 7,772
Posted By schoonder
Re: important new report: benefit of TDM1 after herceptin + perjeta raises?

More work is ongoing to improve on t-dm1 based therapy. Following is an excerpt from a recently published world patent application:

"[159] As can be seen with reference to Figure 7, percent...
Forum: her2group 05-24-2016, 07:01 AM
Replies: 10
Views: 5,396
Posted By schoonder
Re: News. Back on Kadcyla

18-05-2016 Back
Synthon advances clinical evaluation of anti-HER2 ADC SYD985 in an expanded cohort of HER2-positive metastatic breast cancer patients

Synthon Biopharmaceuticals (‘Synthon’)...
Forum: her2group 04-18-2016, 10:50 AM
Replies: 4
Views: 4,321
Posted By schoonder
Re: Anyone on I SPY-2 Trial?

Just reported at AACR
...
Forum: her2group 02-08-2016, 06:23 PM
Replies: 2
Views: 3,200
Posted By schoonder
Re: BioTe pellets

Hi Donna,

Googled subject matter with "biote pellets fda approved" as key and from a variety of returns, selected the two following links.
...
Forum: Articles of Interest 12-08-2015, 07:35 PM
Replies: 0
Views: 20,124
Posted By schoonder
Oncothyreon Announces Data for ONT-380 in HER2-Positive Breast Cancer Patients

http://ir.oncothyreon.com/releasedetail.cfm?ReleaseID=946155
Forum: her2group 08-11-2015, 06:26 PM
Replies: 4
Views: 2,399
Posted By schoonder
Re: PERJETA + Herceptin + docetaxel nearly doubled pCR rates vs Herceptin-- NeoSphere

Yes, unlike the docetaxel component in the NeoSphere trial, the very potent maytansine toxin conjugated to the herceptin, boosted the pCR percentile in the ADAPT trial from 6.7 to 40+
Forum: her2group 08-11-2015, 05:41 PM
Replies: 4
Views: 2,399
Posted By schoonder
Re: PERJETA + Herceptin + docetaxel nearly doubled pCR rates vs Herceptin-- NeoSphere

On a similar note:

Neoadjuvant T-DM1 Shows Promising pCR Rates in HER2+/HR+ Early Breast Cancer | Page 1 Silas Inman @silasinman Published Online: Tuesday, June 23, 2015 - See more at:
...
Forum: her2group 07-31-2015, 09:58 AM
Replies: 26
Views: 13,567
Posted By schoonder
Re: Don't want to give up TDM-1

Since you had to stop an effective treatment with t-dm1 because of a well-known, but manageable side effect, low platelet count, which now has been corrected, I would contact Genentech, producer of...
Forum: her2group 06-15-2015, 12:12 PM
Replies: 3
Views: 1,900
Posted By schoonder
Re: Phase II MARIANNE trial results--T-DM1 treatment not superior to herceptin+taxane

Yes, I was disappointed by the results of the Marianne trial between the T-DM1 arm and T-DM1+Perjeta arm, which came in with a median PFS of 14.1 vs 15.2, and a median DOR of 20.7 vs 21.2 months. The...
Forum: her2group 11-09-2014, 07:26 AM
Replies: 7
Views: 1,694
Posted By schoonder
Re: Arizona Voters " Overwhelmingly " pass Right To Try

Phil, Arizona voters considered this issue a "no brainer". Now it would be nice if this logic could "immediately" be implemented in the policies and directions coming from the FDA.
Forum: her2group 10-23-2014, 06:20 AM
Replies: 235
Views: 184,282
Posted By schoonder
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

To you, your wife, and the medical team THANK YOU for how well you've handled this crisis and the progress thus realized. What an inspiration!
Forum: Herceptin / Tykerb 10-03-2014, 06:29 AM
Replies: 2
Views: 6,967
Posted By schoonder
Re: Does TDM1 cross blood brain barrier

Recently reported abstract at ESMO re: possible t-dm1 activity in her2+ brain metastases.

https://www.webges.com/cslide/library/esmo/browse/search/6Yy#9faC03oC
Forum: her2group 09-20-2014, 05:46 PM
Replies: 20
Views: 3,978
Posted By schoonder
Re: Kadcydla versus neurosurgery and paralysis

I don't know if Kadcyla crosses the blood-brain barrier, but at ESMO Conference, later this month the following abstract will be discussed.

"Abstract...
Forum: her2group 05-15-2014, 01:18 PM
Replies: 235
Views: 184,282
Posted By schoonder
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

ASCO abstract re: T-DM1
"Author(s): Rupert Bartsch, Anna Sophie Berghoff, Margareta Rudas, Elisabeth Bergen, Michael Gnant, Karin Dieckmann, Katja Pinker, Christoph Zielinski, Guenther G. Steger,...
Forum: General Cancer News 10-24-2013, 11:51 AM
Replies: 1
Views: 659
Posted By schoonder
Re: Patient assistance programs help breast cancer patients to learn more about adjuv

New trial soon to start with T-DM1 in adjuvant setting
http://clinicaltrials.gov/ct2/show/NCT01966471?term=t-dm1&rank=27
Forum: Clinical Trials 10-14-2013, 11:53 AM
Replies: 6
Views: 13,070
Posted By schoonder
Re: A Study of PI3-Kinase Inhibitor GDC-0941

Report from SABCS 2010
[P6-15-02] A Phase Ib Study Evaluating Safety, Tolerability, Pharmacokinetics (PK), and Activity of the Phosphoinositide-3 Kinase (PI3K) Inhibitor GDC-0941 in Combination with...
Forum: Clinical Trials 10-14-2013, 06:20 AM
Replies: 6
Views: 13,070
Posted By schoonder
Re: A Study of PI3-Kinase Inhibitor GDC-0941

GDC-0941 is also being evaluated in a phase I trial with T-DM1. Trial is active, no longer recruiting candidates and approaching anticipated completion date....
Forum: her2group 09-13-2013, 06:03 AM
Replies: 11
Views: 3,470
Posted By schoonder
Re: How do you boost your platelets on Kadcyla

Since reduction of platelet count is a known side effect of kadcyla and is closely monitored by prescribing oncologists, one would think Roche, as owner of product, would've researched and published...
Forum: her2group 09-03-2013, 09:39 AM
Replies: 21
Views: 5,648
Posted By schoonder
Re: Has anyone been on TDM-1 for more than 2 years?

Phil, since t-dm1 doesn't cross bb barrier and drug's effectiveness prolonging life, and thus increasing possibility of disease metastisizing into brain, I'm somewhat surprised that Genentech which...
Forum: General Cancer News 08-03-2013, 05:41 AM
Replies: 3
Views: 842
Posted By schoonder
Re: Research aims to provide physicians more targeted approach to treating ER+ breast

Driving force behind I-SPY2 trial is to reduce size of phaseIII trials in order to get new, effective drugs approved for early BC indications in most expedient fashion....
Forum: her2group 06-13-2013, 05:52 PM
Replies: 16
Views: 7,826
Posted By schoonder
Re: How long does it take for Kadcyla to work?

Great news yanyan, very happy your doctor is seeing signs drug is doing the job.
Forum: her2group 06-13-2013, 10:21 AM
Replies: 16
Views: 7,826
Posted By schoonder
Re: How long does it take for Kadcyla to work?

Think Phil got it right, difficult to predict exact moment results of kadcyla, a personalized medicine, can be established. Linked article shows signs of efficacy, improved breathing, to occur after...
Forum: her2group 06-06-2013, 08:07 AM
Replies: 18
Views: 2,160
Posted By schoonder
Re: "Help Me"

Penny, one of the Emilia trial inclusion criteria, a trial which became the basis for T-DM1 approval, required that patients had received:

"Prior treatment for breast cancer in the adjuvant,...
Forum: her2group 05-09-2013, 05:42 AM
Replies: 27
Views: 4,101
Posted By schoonder
Re: One year of TDM1. NED!

Great news Michka.
Kadcyla has now also been approved for Swiss use.

http://www.foxbusiness.com/news/2013/05/07/roche-kadcyla-breast-cancer-drug-approved-for-swiss-use/
Showing results 1 to 25 of 175

 
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