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Search: Posts Made By: gdpawel
Forum: Breast Cancer News 03-13-2013, 03:10 PM
Replies: 3
Views: 6,893
Posted By gdpawel
Use Functionality to Inform Genomics

The PI3K pathway is an area of rapidly growing interest as new compounds target this key regulatory protein complex. Both selective and non-selective (pan PI3K) inhibitors are in clinical testing....
Forum: Breast Cancer News 03-13-2013, 03:09 PM
Replies: 3
Views: 6,893
Posted By gdpawel
Resistance To Anti-HER2 Therapy May Be Delayed By Treatment Targeting PI3K

Patients with HER2-positive breast cancer being treated with anti-HER2 therapy may be able to prevent or delay resistance to the therapy with the addition of a phosphatidylinositol-3 (PI3K) kinase...
Forum: Breast Cancer News 03-13-2013, 03:08 PM
Replies: 3
Views: 6,893
Posted By gdpawel
A Multitude of Pathways/Mechanisms

Targeted therapy is designed to block a specific gene or protein that has a critical role in the survival, growth, invasion, or metatasis of a specific cancer cell. It takes advantage of the biologic...
Forum: Breast Cancer News 03-13-2013, 03:07 PM
Replies: 3
Views: 6,893
Posted By gdpawel
Why Her-2 has not been a magic bullet in Breast Cancer

Nature Reviews Drug Discovery 6, 111 (February 2007) | doi:10.1038/nrd2253

Anticancer drugs: Escaping inhibition

Peter Kirkpatrick

The success of the ABL-kinase inhibitor imatinib in the...
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