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Search: Posts Made By: gdpawel
Forum: Articles of Interest 03-16-2014, 06:35 PM
Replies: 3
Views: 6,187
Posted By gdpawel
Is Genomic Sequencing Ready for Prime Time in Drug Selection?

Next-generation sequencing (NGS) technologies have come a long way since 1977 when Frederick Sanger developed chain-termination sequencing, but are they ready for prime time in drug selection?
...
Forum: Articles of Interest 03-16-2014, 06:34 PM
Replies: 3
Views: 6,187
Posted By gdpawel
Genome-wide sequencing in cancer; not ready for prime time

(Reuters Health) - Routine genome-wide screening of cancers is likely a long way off, a new paper says.

The technology, known as next-generation sequencing, promises to revolutionize doctors'...
Forum: Articles of Interest 03-16-2014, 06:32 PM
Replies: 3
Views: 6,187
Posted By gdpawel
Whole genome sequencing; not ready for prime time

A test of the utility of whole-genome sequencing (WGS) on 12 genetically healthy adults reveals several shortcomings, according to a study published in the March 12 issue of JAMA.

The report...
Forum: Articles of Interest 02-27-2014, 12:06 AM
Replies: 16
Views: 12,152
Posted By gdpawel
Re: The Downside To Clinical Trials

Yes. Very depressing!
Forum: Articles of Interest 02-26-2014, 04:09 PM
Replies: 16
Views: 12,152
Posted By gdpawel
JAMA papers raise questions about FDA drug and device approval

Gary Schwitzer

HealthNewsReview.org

An important series of papers was published in the Journal of the American Medical Association this week.

“Clinical Trial Evidence Supporting FDA...
Forum: Articles of Interest 02-26-2014, 04:07 PM
Replies: 16
Views: 12,152
Posted By gdpawel
Randomized Clinical Trial Paradigm

Cancer clinical trials can exclude those patients most likely to benefit from certain treatments. And institutions usually offer treatments based only on standard protocols. Has cancer medicine...
Forum: Articles of Interest 02-26-2014, 04:06 PM
Replies: 16
Views: 12,152
Posted By gdpawel
Further Information on The Downside To Clinical Trials

Robert A. Nagourney, M.D.

The recent blog “The Downside To Clinical Trials” described some of the pitfalls of modern cancer research and the clinical trial process. It has engendered an active...
Forum: Articles of Interest 02-26-2014, 04:04 PM
Replies: 16
Views: 12,152
Posted By gdpawel
The Downside To Clinical Trials

Robert A. Nagourney, M.D.

As the practice of medicine has moved from a profession to an industrial undertaking, this most human of experiences has fallen prey to the dictates of the American...
Forum: Articles of Interest 02-20-2014, 10:21 AM
Replies: 4
Views: 5,878
Posted By gdpawel
Re: Test Shown to Reduce Early Cancer Deaths is Now Available to Patients

'lizbeth

Personally, I find your statement profound: "I can't believe they gave the same chemo to everyone".
Forum: Articles of Interest 02-20-2014, 12:16 AM
Replies: 4
Views: 5,878
Posted By gdpawel
Dr. Weisenthal Replies to ASCO Post

Replies to comments regarding personalized cancer treatment, as published in the December 15, 2013 "ASCO Post" (American Society of Clinical Oncology publication).

By Larry Weisenthal, MD...
Forum: her2group 12-16-2013, 10:30 PM
Replies: 6
Views: 3,981
Posted By gdpawel
Dr. Weisenthal Replies to ASCO Post

Replies to comments regarding personalized cancer treatment, as published in the December 15, 2013 "ASCO Post" (American Society of Clinical Oncology publication).

By Larry Weisenthal, MD...
Forum: Breast Cancer News 12-12-2013, 03:59 PM
Replies: 3
Views: 12,037
Posted By gdpawel
Avastin Misses Mark Again in Breast Cancer?

The addition of bevacizumab (Avastin) to standard adjuvant therapy for HER2-positive breast cancer failed to improve invasive disease-free survival (iDFS) in a randomized clinical trial.

Patients...
Forum: Breast Cancer News 12-12-2013, 03:57 PM
Replies: 3
Views: 12,037
Posted By gdpawel
BEATRICE: Adjuvant chemotherapy/Avastin (Bevacizumab)

The first presentation of the BEATRICE trial, evaluating adjuvant Avastin with a physician’s choice taxane- and/or anthracycline-based regimen in patients with triple-negative disease, was at the...
Forum: Breast Cancer News 12-12-2013, 03:56 PM
Replies: 3
Views: 12,037
Posted By gdpawel
Does BEATRICE Spell the End of Avastin (bevacizumab) in Breast Cancer?

Direct anti-tumor and anti-vascular effects were studied of Tykerb, Nexavar and Avastin in fresh biopsy specimens of breast cancer and presented at the American Society of Clinical Oncology Breast...
Forum: Breast Cancer News 12-12-2013, 03:54 PM
Replies: 3
Views: 12,037
Posted By gdpawel
Avastin (bevacizumab) Fails in Advanced, HR-Positive Breast Cancer?

All women in the BEATRICE trial with triple negative early breast cancer received chemotherapy. One half were also given Avastin (bevacizumab). There was no difference in outcome with or without...
Forum: her2group 12-12-2013, 03:49 PM
Replies: 6
Views: 3,981
Posted By gdpawel
pCR Arrives as a Standard Measure in Breast Cancer

A new study strengthens the evidence that pathological complete response (pCR) is a good surrogate marker of longer-term efficacy in the neoadjuvant drug treatment of breast cancer.

pCR, which is...
Forum: Articles of Interest 11-15-2013, 08:35 PM
Replies: 4
Views: 5,878
Posted By gdpawel
About this CLL clinical trial

To my knowledge, there hasn't been a clinical trial of any predictive test to show clinical benefit in a prospective randomized trial, in which patients are randomized to treatment on the basis of...
Forum: Articles of Interest 11-15-2013, 08:34 PM
Replies: 4
Views: 5,878
Posted By gdpawel
Test Shown to Reduce Early Cancer Deaths is Now Available to Patients

Huntington Beach, CA - SignatureCLL announced that the first laboratory test ever shown in a clinical trial to improve one year survival rates in cancer is now available to patients with chronic...
Forum: General Cancer News 11-06-2013, 11:57 PM
Replies: 7
Views: 2,294
Posted By gdpawel
Cancer Patients Who Get Better, Get Better

Robert A. Nagourny, M.D.
Rational Therapeutics

A study published in the October 20 Journal of Clinical Oncology (Use of early tumor shrinkage to predict long-term outcome in metastatic colorectal...
Forum: Articles of Interest 11-01-2013, 01:49 PM
Replies: 9
Views: 7,822
Posted By gdpawel
Heat-shock factor reveals its unique role in supporting highly malignant cancers

Whitehead Institute researchers have found that increased expression of a specific set of genes is strongly associated with metastasis and death in patients with breast, colon, and lung cancers. Not...
Forum: Articles of Interest 11-01-2013, 01:47 PM
Replies: 9
Views: 7,822
Posted By gdpawel
Two HSP90 Cancer Trials Fall Short of Goal

Robert A. Nagourney, M.D.

Two related clinical trials were reported in the last several months describing the use of heat shock protein 90 (HSP90) inhibitors in lung cancer. Both trials fell short...
Forum: Articles of Interest 10-29-2013, 12:31 PM
Replies: 9
Views: 16,229
Posted By gdpawel
Laboratory Oncology

Well put! As you may be well aware, functional profiling is not a simple, turn-key solution. It is more a professional service, more than a simple laboratory test. It is sometimes thought of as...
Forum: Articles of Interest 10-28-2013, 08:53 AM
Replies: 9
Views: 16,229
Posted By gdpawel
Dazed and Confused About Molecular Data?

John L. Marshall, M.D.
Medscape Oncology

I have been focused these past few months on the concept of molecular profiling. For the cost of a CT scan, you can send your patient's tumor for a deep...
Forum: Articles of Interest 10-28-2013, 08:51 AM
Replies: 9
Views: 16,229
Posted By gdpawel
Analyte-based Tests vs Functional Platforms

Robert A. Nagourney, M.D.
Medical and Laboratory Director
Rational Therapeutics, Inc.
Long Beach, California

I recently had an interesting conversation with a physician regarding her patient...
Forum: her2group 10-22-2013, 04:12 PM
Replies: 6
Views: 3,981
Posted By gdpawel
Analyte-based Tests vs Functional Platforms

Robert A. Nagourney, M.D.
Medical and Laboratory Director
Rational Therapeutics, Inc.
Long Beach, California

I recently had an interesting conversation with a physician regarding her patient...
Showing results 51 to 75 of 500

 
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