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Search took 0.11 seconds; generated 103 minute(s) ago. Search: Posts Made By: donocco
Forum: her2group 07-06-2020, 12:20 PM
Replies: 2
Views: 4,492
Posted By donocco
Re: GREAT NEWS: FDA approves at home submit dual anti-her2/3 therapy

Im just curious. Suppose one of the women on the board (anyone) who has been doing well with Her 2 Neu positive breast cancer were just diagnosed today. What therapy would you prefer to treat the Her...
Forum: her2group 06-25-2020, 12:20 PM
Replies: 4
Views: 9,965
Posted By donocco
Re: Tucatinib Is Active Against Brain Metastases in HER2+ Breast Cancer

They don't use Tucatanib alone. It is combined with Xeloda 1000mg per square meter twice a day.

I learned a quick formula for determining Body Surface Area in pharmacy school long ago....
Forum: her2group 06-18-2020, 02:58 PM
Replies: 4
Views: 9,965
Posted By donocco
Re: Tucatinib Is Active Against Brain Metastases in HER2+ Breast Cancer

Imteresting.
One thing about Tucatanib surprised me when I looked at the package insert. It can cause severe diarrhea. When it first was being researched they didn't think it would because it wasn't...
Forum: Herceptin / Tykerb 06-11-2020, 12:52 PM
Replies: 10
Views: 16,340
Posted By donocco
Re: After 9 years on Herceptin,heart ef crash

At the risk of seeming like Im splitting hairs Carvedilol is a combo Beta and Alpha sympatheric nervous system inhibitor not an Ace inhibitor. The side effects are different.
The important thing is...
Forum: her2group 06-01-2020, 01:23 PM
Replies: 1
Views: 3,828
Posted By donocco
Re: Tucatinib Plus Trastuzumab and Capecitabine for Previously Treated HER2+ Brea

Very informative. Thank you.

However it is important to know Tucatanib has significant side effects. Severe diarrhea serious liver toxicity fatigue, rash, hand foot syndrome anemia anorexia...
Forum: General Cancer News 04-23-2020, 01:13 PM
Replies: 1
Views: 1,146
Posted By donocco
Re: AMPK activation by anti-diabetes drug promotes survival of dormant breast cancer

From what all I have read, and I research a lot, for the majority of situations the opposite seems to be true. AMPK or Adenonine Monophosphate Kinase is probably the most important anti-cancer...
Forum: her2group 03-22-2020, 11:16 AM
Replies: 1
Views: 3,584
Posted By donocco
Re: any hope of getting insurance companies to cover hylecta in view of covid19 pande

Lani

Of course I cant say for sure but when I first read about the product insurance was the ist thing that went into my mind. I did a lot of work with Tobramycin dosage iv when I worked as a...
Forum: her2group 02-25-2020, 01:04 PM
Replies: 22
Views: 23,417
Posted By donocco
Re: ENHERTU aka DS8401A

Flori

Glad to hear the good part of the news. Im going by memory but Im pretty sure Varubi works like Emend (Aprepitant) on the Substance P/Neurokinin receptors and may well offer anti-nausea...
Forum: Articles of Interest 01-21-2020, 12:20 PM
Replies: 6
Views: 6,765
Posted By donocco
Re: Is anyone familiar with using Noscapine for breast cancer treatment?

Marcia

Ill check the articles out. This is the first time I ever heard of this about Noscapine but apparently some of the research goes back to the 1950s
Forum: Articles of Interest 01-20-2020, 12:37 PM
Replies: 6
Views: 6,765
Posted By donocco
Re: Is anyone familiar with using Noscapine for breast cancer treatment?

I read a little about it due to your post. In the test tube it enhances apoptosis or cancer cell death by increasing the protein that induces apoptosis (called BAX) and decreasing te protein that ...
Forum: General Cancer News 12-30-2019, 10:45 AM
Replies: 1
Views: 642
Posted By donocco
Re: Combination treatment reduces breast cancer development in mice

Interesting

For those that might be interested. There are proteins called histones that are very electropositive chemically. Genes tend to be very electro-negative. Cells including cancer cells...
Forum: her2group 12-11-2019, 12:37 PM
Replies: 1
Views: 3,263
Posted By donocco
Re: SABCS: Tucatinib 'game changing' vs HER2+ MBC, especially w brain mets

Lani

This is good news. Tucatinib is the drug that went by the experimental name of ONT-380 or something like that, correct. If it is it has good central nervous system penetration and the...
Forum: Herceptin / Tykerb 12-04-2019, 10:57 PM
Replies: 10
Views: 16,340
Posted By donocco
Re: After 9 years on Herceptin,heart ef crash

Diana

I still wonder what would happen if you were put on an ACE inhibitor along with the coreg , temporarily stopped the Herceptin, waited until the LVEF function increased, then went back on...
Forum: Herceptin / Tykerb 12-03-2019, 01:38 PM
Replies: 10
Views: 16,340
Posted By donocco
Re: After 9 years on Herceptin,heart ef crash

Diana

I did some very quick research on the subject. If you put "Cardiac side effects of herceptin" in google there is an article (a long one) from the nci that discusses this. They have a lot...
Forum: her2group 11-20-2019, 03:13 PM
Replies: 7
Views: 4,679
Posted By donocco
Re: Pregnancy after Her2+

I don't think the HER 2 Neu plus is that important as far as pregnancy goes. What is more important is how estrogen positive you are and possibly how progesterone positive. Even if you are ER + and ...
Forum: her2group 10-21-2019, 12:24 PM
Replies: 1
Views: 2,798
Posted By donocco
Re: seeking your thought particularly experience with "Block Center for..."

Nguyen

Im 100% for complementary therapy. I know nothing about the Block center. They may be skillfull and idealistic and effective or they may be like Cancer Treatment Centers of America which...
Forum: General Cancer News 10-15-2019, 09:58 AM
Replies: 1
Views: 654
Posted By donocco
Re: Risk of genetic seizure disorder: new scoring system

Everything is genetic but genes are relative. A lot of cases of epilepsy are due to head injuries. Still not everyone with the same degree of injury develops epilepsy afterward. If someone has a...
Forum: General Cancer News 10-08-2019, 03:24 PM
Replies: 1
Views: 891
Posted By donocco
Re: New understanding of breast cancer metastasis to bone

Another reason many cancers spread to the bones is that the bones are very rich in cells that produce Interleukin 6 and this is important in many areas of cancer cell proliferation and angiogenesis....
Forum: General Cancer News 10-07-2019, 12:40 PM
Replies: 2
Views: 1,153
Posted By donocco
Re: Novel drug may be the answer in battling resistance in aggressive breast cancer

Ill see what else I can find about BOS172722. Getting info on the internet is not as quick and easy as in the past. Look up the work of Dr. Linda Vahdat. She treated triple negative breast cancer...
Forum: General Cancer News 10-07-2019, 12:38 PM
Replies: 2
Views: 1,153
Posted By donocco
Re: Novel drug may be the answer in battling resistance in aggressive breast cancer

I could not find to much info about BOS172722. Apparently the human trials are just starting. They are going to combine it with IV Taxol to see the effect on cancers, particularly triple negative...
Forum: General Cancer News 10-07-2019, 12:15 PM
Replies: 1
Views: 880
Posted By donocco
Re: Understanding treatment and prognosis of male breast cancer

Apparently men can get both inflammatory and Her 2 Neu positive breast cancer. Usually the male breast cancers are both estrogen and progesterone receptor positive. What is rare in men is DCIS, the...
Forum: her2group 10-03-2019, 12:48 PM
Replies: 10
Views: 12,026
Posted By donocco
Re: Wife's Demise

Ajit

Very sorry to hear of this. The words are lame but it is all I can say

Paul
Forum: General Cancer News 09-18-2019, 10:08 PM
Replies: 2
Views: 759
Posted By donocco
Re: NMDAR receptor is responsible for breast-to-brain metastases, shows study

I think there are already drugs on the market that block glutamate in the brain. Maybe Riluazole, I think Ketamine. Ill have to research gthis. It would be tremendous if we could prevent brain mets
...
Forum: General Cancer News 09-18-2019, 10:06 PM
Replies: 2
Views: 759
Posted By donocco
Re: NMDAR receptor is responsible for breast-to-brain metastases, shows study

Interesting. I think there are medications on the market that block glutamate in the brain. Ill have to research this.
Forum: her2group 08-30-2019, 09:51 PM
Replies: 9
Views: 7,358
Posted By donocco
Re: Tamoxifen - 8-10 years?

I looked this p in Pub Med. There was an article in Ther Adv Med Oncology June 18 2018
that addressed this question. The conclusion was that extended Anti-Hormonal therapy with either Tamoxifen or...
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