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Search took 0.11 seconds; generated 60 minute(s) ago. Search: Posts Made By: gdpawel
Forum: her2group 11-18-2011, 06:41 PM
Replies: 14
Views: 3,968
Posted By gdpawel
Avastin revoked for breast cancer

I was reminded for the record, the formal indication that the FDA revoked involved Avastin used in combination with the cancer drug paclitaxel (Taxol) for those patients who have not been treated...
Forum: Articles of Interest 11-18-2011, 12:02 PM
Replies: 6
Views: 3,649
Posted By gdpawel
FDA Withdraws Avastin's Breast Cancer Indication

According to Merriall Goozner (who occasionaly writes for the Journal of the National Cancer Institute), two clinical trials showed no improvement in mortality among women with metastatic breast...
Forum: her2group 11-18-2011, 12:00 PM
Replies: 14
Views: 3,968
Posted By gdpawel
FDA Withdraws Avastin's Breast Cancer Indication

According to Merriall Goozner (who occasionaly writes for the Journal of the National Cancer Institute), two clinical trials showed no improvement in mortality among women with metastatic breast...
Forum: Articles of Interest 11-07-2011, 10:50 PM
Replies: 3
Views: 3,329
Posted By gdpawel
Src inhibitors may prove beneficial in breast cancer therapy

Estrogen, which binds estrogen receptor alpha (ER-alpha), is a risk factor for breast cancer development. However, one-third of new breast cancers lack detectable ER-alpha. These ER-alpha negative...
Forum: Articles of Interest 11-07-2011, 10:35 PM
Replies: 4
Views: 2,679
Posted By gdpawel
Re: Embryonic signal drives pancreatic cancer and offers a way to kill it

http://www.nature.com/
Forum: General Cancer News 11-07-2011, 07:23 PM
Replies: 11
Views: 3,589
Posted By gdpawel
A Look At Systems Biology And Cellular Networking

Systems biology is a holistic approach to the study of how a living organism emerges from the interactions of the individual elements that make up its constituent cells. Embracing a broad range of...
Forum: Articles of Interest 11-07-2011, 07:08 PM
Replies: 4
Views: 2,679
Posted By gdpawel
Hedgehog signaling is a potent regulator of angiogenesis

Rich

This looks similar to research being done by an international team from Monash, Stanford and John Hopkins universities which represents not just the potential for new drugs but also a novel...
Forum: her2group 11-02-2011, 08:04 PM
Replies: 3
Views: 1,913
Posted By gdpawel
Re: Molecular subtyping in breast cancer

Rich

I'll let New York Times Gina Kolata explain the faults of gene signature technology.

http://www.nytimes.com/2011/07/19/health/19gene.html?pagewanted=all

Predictive accuracy is the...
Forum: General Cancer News 10-18-2011, 04:11 PM
Replies: 11
Views: 3,589
Posted By gdpawel
Gene Expression In Cancer Regulated By Vast Hidden Network

Researchers at Columbia University Medical Center (CUMC) and two other institutions have uncovered a vast new gene regulatory network in mammalian cells that could explain genetic variability in...
Forum: Breast Cancer Newsfeed 10-18-2011, 04:07 PM
Replies: 4
Views: 1,838
Posted By gdpawel
Functional Analysis of PARP Inhibitors in Human Tumor Primary Cultures

Functional analysis of PARP inhibitors AZD 2281 and BSI-201 in human tumor primary cultures: A comparison of activity and examination of synergy with cytotoxic drugs.

Sub-category: DNA Repair and...
Forum: Breast Cancer Newsfeed 10-18-2011, 04:06 PM
Replies: 4
Views: 1,838
Posted By gdpawel
Evolutionary History Of The PARP Enzyme

The recently analyzed evolutionary history of the poly(ADP-ribose)polymerase (PARP) found these proteins in eukaryotes, a wide range of organisms - animals, plants, molds, fungi, algae and protozoa -...
Forum: Breast Cancer Newsfeed 10-18-2011, 04:03 PM
Replies: 2
Views: 1,694
Posted By gdpawel
Is Precision Therapeutics abandoning ChemoFx?

Precision had announced a new product line called BioSpeciFx to idenify molecular targets within a patient's cell. They use the information generated by BioSpeciFx in combination with ChemoFx to look...
Forum: General Cancer News 09-22-2011, 10:22 AM
Replies: 11
Views: 3,589
Posted By gdpawel
Research in Combining Targeted Agents Faces Numerous Challenges

In a conference sponsored by the Institute of Medicine, scientists representing both public and private institutions examined the obstacles that confront researchers in their efforts to develop...
Forum: Articles of Interest 09-21-2011, 11:35 PM
Replies: 24
Views: 10,398
Posted By gdpawel
Targeted Therapies for Cancer Confronts Hurdles

In a conference sponsored by the Institute of Medicine, scientists representing both public and private institutions examined the obstacles that confront researchers in their efforts to develop...
Forum: Articles of Interest 09-21-2011, 11:34 PM
Replies: 24
Views: 10,398
Posted By gdpawel
Research in Combining Targeted Agents Faces Numerous Challenges

By Margot J. Fromer
ASCO Post
September 1, 2011, Volume 2, Issue 13

If the clinical trials endeavor in oncology is falling short of its goals and if targeted agents have not kept their promise,...
Forum: General Cancer News 09-02-2011, 08:43 PM
Replies: 11
Views: 3,589
Posted By gdpawel
The cancer cell is but a small component of the cancer

Cell-based functional profiling labs have recognized the interplay between cells, stroma, vascular elements, cytokines, macrophages, lymphocytes and other environmental factors. This lead to their...
Forum: General Cancer News 09-02-2011, 08:41 PM
Replies: 11
Views: 3,589
Posted By gdpawel
Cancer’s Secrets Come Into Sharper Focus

An article in the New York Times, "Cancer's Secrets Come into Sharper Focus" examined the growing complexity of cancer research. This article explored the growing realization that human biology is...
Forum: General Cancer News 09-02-2011, 08:40 PM
Replies: 11
Views: 3,589
Posted By gdpawel
The Future of Cancer Research Lies Behind Us

The TED (Technology Entertainment Design) conferences have been held annually for almost two decades. It draws together innovators in a broad spectrum of disciplines. With invited speakers ranging...
Forum: General Cancer News 09-02-2011, 08:38 PM
Replies: 11
Views: 3,589
Posted By gdpawel
Personalized Cancer Cytometrics More Accurate than Molecular Gene Testing

Clinical Trial Finds Personalized Cancer Cytometrics More Accurate than Molecular Gene Testing

In the first head-to-head clinical trial comparing gene expression patterns with Personalized Cancer...
Forum: General Cancer News 09-02-2011, 08:36 PM
Replies: 11
Views: 3,589
Posted By gdpawel
'Systems biology' study of breast cancer

Using a 'systems biology' approach, which focuses on understanding the complex relationships between biological systems, to look under the hood of an aggressive form of breast cancer, researchers for...
Forum: Articles of Interest 08-30-2011, 02:29 PM
Replies: 3
Views: 4,309
Posted By gdpawel
Re: circulating tumor cells as a surrogate for response to treatment

Rich

I have written before about how to go about a collaborative approach. You could identify informative gene expression patterns, using cell-death cell culture assays, to look for patterns of...
Forum: Articles of Interest 08-30-2011, 01:54 PM
Replies: 3
Views: 4,309
Posted By gdpawel
Biocept and Clarient Announce Collaboration on First Test for Circulating Tumor Cells

http://www.prnewswire.com/news-releases/biocept-and-clarient-announce-collaboration-on-first-test-for-circulating-tumor-cells-and-her2-status-in-breast-cancer-patients-128327503.html

Rich
...
Forum: Articles of Interest 08-28-2011, 09:50 PM
Replies: 6
Views: 3,367
Posted By gdpawel
Re: FDA to alter rules for cancer drug cocktails

According to an article in the Journal of the National Cancer Institute, it is becoming increasingly evident that cancers are dependent on a number of altered molecular pathways and can develop...
Forum: Articles of Interest 08-20-2011, 06:22 PM
Replies: 9
Views: 4,549
Posted By gdpawel
Re: The future of cancer lies behind us

Amy

Targeted drugs are specifically designed to block one or more critical pathways involved in cancer-cell growth and metastases. The development of these therapies stems from advances in...
Forum: Articles of Interest 08-20-2011, 02:59 PM
Replies: 9
Views: 4,549
Posted By gdpawel
Re: The future of cancer lies behind us

LOL!

With the most recent study published in the Journal of Translational Medicine, "Peritoneal carcinomatosis from ovarian cancer: chemosensitivity test and tissue markers as predictors of...
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