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Search took 0.11 seconds; generated 60 minute(s) ago. Search: Posts Made By: gdpawel
Forum: Articles of Interest 05-06-2014, 09:54 PM
Replies: 16
Views: 12,152
Posted By gdpawel
Personalized Cancer Care: N-of-1

Robert A. Nagourney, M.D.

The New York Yankees catcher Yogi Berra famous quote, “Déj* vu all over again,” reminds me of the growing focus on the concept of “N- of-1.” For those of you...
Forum: Articles of Interest 04-17-2014, 08:15 PM
Replies: 1
Views: 5,135
Posted By gdpawel
Comparative Effectiveness Research in Cancer Medicine

One good example of Comparative Effectiveness Research in cancer medicine was a Duke University cost savings study on the impact of a chemoresponse assay on treatment costs for recurrent ovarian...
Forum: Articles of Interest 04-17-2014, 08:03 PM
Replies: 8
Views: 7,679
Posted By gdpawel
The Revival of Cancer Immunotherapy

An old idea for treating cancer is yielding impressive results on cancer patients—and lots of attention from drug companies.

New medicines that shrink tumors and have beneficial effects lasting...
Forum: Articles of Interest 04-17-2014, 08:02 PM
Replies: 8
Views: 7,679
Posted By gdpawel
Training the immune system to fight cancer

The potential to harness the body's immune system to fight cancer may finally prove itself on a large scale in the next couple of years. Scores of new immunotherapy vaccines and other immune system...
Forum: Articles of Interest 04-17-2014, 08:01 PM
Replies: 8
Views: 7,679
Posted By gdpawel
Cancer Immunology Named 'Breakthrough of the Year'

Cancer immunology has been selected as the "Breakthrough of the Year" by the editors of Science, the flagship journal of the American Association for the Advancement of Science. A report on the...
Forum: Articles of Interest 04-17-2014, 08:00 PM
Replies: 8
Views: 7,679
Posted By gdpawel
Monoclonal antibody drugs for cancer treatment: How they work

If you're considering monoclonal antibody therapy as part of your cancer treatment, learn about these drugs and carefully weigh the benefits against the potential side effects.

By Mayo Clinic...
Forum: Articles of Interest 04-17-2014, 07:58 PM
Replies: 8
Views: 7,679
Posted By gdpawel
Understanding Immunotherapy

Immunotherapy (also called biologic therapy or biotherapy) is a type of cancer treatment designed to boost the body's natural defenses to fight the cancer. It uses materials either made by the body...
Forum: Articles of Interest 04-17-2014, 07:57 PM
Replies: 8
Views: 7,679
Posted By gdpawel
Tumor cell escape from immune attack

Tumor cell evolution enables cancer cells to evade destruction by the immune system. Cells that can be destroyed are destroyed. What is left is resistant to immune destruction. The mechanisms of...
Forum: Articles of Interest 04-17-2014, 07:56 PM
Replies: 8
Views: 7,679
Posted By gdpawel
Immunotherapy Cancer 'Vaccine' For Metastatic Cancers

Preclinical, laboratory studies suggest immunotherapy could potentially work like a vaccine against metastatic cancers.

Results from the recent study show the therapy could treat metastatic...
Forum: Articles of Interest 04-17-2014, 07:55 PM
Replies: 8
Views: 7,679
Posted By gdpawel
Immunotherapy: A prematurely-abandoned treatment option

Larry Weisenthal, M.D., PhD.
Medical and Lab Director
Weisenthal Cancer Group; Huntington Beach, CA

Clinical trials are warranted to test macrophage-activating biologic response modifiers...
Forum: Articles of Interest 04-17-2014, 07:54 PM
Replies: 8
Views: 7,679
Posted By gdpawel
Immunological Research: A multi-faceted approach to curing disease

Animal models of human disease have been a tremendous asset to the development of cures for disease. Unfortunately, animal physiology is often not identical to human and more appropriate models are...
Forum: Breast Cancer News 04-10-2014, 01:33 PM
Replies: 8
Views: 14,081
Posted By gdpawel
The cyclin-dependent kinase inhibitors

These kinase inhibitors can work across various types of cancer, but often only extend life by around three to six months. However, researchers believe they can unlock the true potential of these...
Forum: Breast Cancer News 04-10-2014, 01:32 PM
Replies: 8
Views: 14,081
Posted By gdpawel
Bemaciclib Seems Safe, Effective for Advanced Disease

In an early trial, an experimental breast cancer drug stopped disease growth and shrank tumors by more than 30 percent in some patients.

The pill, bemaciclib, was safe and well-tolerated by women...
Forum: Breast Cancer News 04-10-2014, 01:31 PM
Replies: 8
Views: 14,081
Posted By gdpawel
Palbociclib stymies cancer progression but falls short on survival

Palbociclib doubled the average amount of progression-free survival (PFS) time among patients with advanced breast cancer. But in the first detailed glimpse of its impact on overall survival (OS) - a...
Forum: Breast Cancer News 04-10-2014, 01:30 PM
Replies: 8
Views: 14,081
Posted By gdpawel
Cancer is not a genomic disorder, but a metabolic disorder

Robert A. Nagourney, M.D.

A study conducted by Canadian investigators and reported in the September 1, 2013 issue of the Journal of Clinical Oncology examined the impact of Metformin use on...
Forum: Breast Cancer News 04-10-2014, 01:28 PM
Replies: 8
Views: 14,081
Posted By gdpawel
Triple Negative Breast Cancer: Worse or Just Different?

Robert A. Nagourney, M.D.

The term “triple negative breast cancer” (TNBC) is applied to a subtype of breast cancers that do not express the estrogen or progesterone receptors. Nor do they...
Forum: Articles of Interest 04-08-2014, 02:05 PM
Replies: 16
Views: 12,152
Posted By gdpawel
Re: The Downside To Clinical Trials

I have no idea who the philanthropist would be but the private laboratories who offered all these years to supply free assays for a clinical trial purposes have been RT & WCG.
Forum: Articles of Interest 04-08-2014, 01:38 PM
Replies: 16
Views: 12,152
Posted By gdpawel
Re: The Downside To Clinical Trials

How do you get a study with CRSA for breast cancer (or any solid cancers)?

There is one problem: (1) Funding.

In the case of most private labs, the relevant technologies are completely public...
Forum: Breast Cancer News 03-27-2014, 11:51 PM
Replies: 13
Views: 15,893
Posted By gdpawel
Is It Ethical to Deny Cancer Patients Functional Analyses?

Robert A. Nagourney, M.D.

The ethical standards that govern human experimentation have become an important topic of discussion. Clinical trials are conducted to resolve medical questions while...
Forum: Breast Cancer News 03-27-2014, 11:49 PM
Replies: 13
Views: 15,893
Posted By gdpawel
Scientists challenge the genetic interpretation of biology

A proposal for reformulating the foundations of biology, based on the 2nd law of thermodynamics and which is in sharp contrast to the prevailing genetic view, is published in the Journal of the Royal...
Forum: Breast Cancer News 03-27-2014, 11:48 PM
Replies: 13
Views: 15,893
Posted By gdpawel
Pharmacogenomics can be defined as the study of...

Pharmacogenomics can be defined as the study of how a person’s genetic makeup determines response to a drug. Although any number of labs and techniques can detect mutant genes, this area of...
Forum: Breast Cancer News 03-27-2014, 11:47 PM
Replies: 13
Views: 15,893
Posted By gdpawel
First FDA Authorization for Next-Generation Sequencer

Francis S. Collins, M.D., Ph.D., and Margaret A. Hamburg, M.D.
N Engl J Med 2013; 369:2369-2371December 19, 2013DOI: 10.1056/NEJMp1314561

Article

This year marks 60 years since James Watson...
Forum: Breast Cancer News 03-27-2014, 11:45 PM
Replies: 13
Views: 15,893
Posted By gdpawel
Genome-wide sequencing in cancer: not ready for prime time

(Reuters Health) - Routine genome-wide screening of cancers is likely a long way off, a new paper says.

The technology, known as next-generation sequencing, promises to revolutionize doctors'...
Forum: her2group 03-18-2014, 05:08 PM
Replies: 4
Views: 1,937
Posted By gdpawel
Yes, stem cells are acutely attuned to other cells in their microenvionment

Interesting, but the key words are "fruit flies". In-vitro cell assay experts remain to be convinced that even "mouse" tumors are all that relevant.

Yes, there are modern methods of in-vitro cell...
Forum: Articles of Interest 03-16-2014, 06:37 PM
Replies: 3
Views: 6,187
Posted By gdpawel
Debating Next-Generation Deep Sequencing

At ESMO, experts assess the clinical use of genome sequencing

Vienna—Should oncologists begin using deep genome sequencing in their clinical practice? Next-generation sequencing (NGS)...
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