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Search took 0.03 seconds; generated 56 minute(s) ago. Search: Posts Made By: Rolepaul
Forum: her2group 05-06-2015, 10:48 AM
Replies: 24
Views: 7,486
Posted By Rolepaul
Re: When work really hits home

Like you, I work in the industry, but as a consultant. Every day is something different for me. But at night, I get to focus on HER+ issues. Hopefully the monster can be helped by people like you...
Forum: her2group 05-06-2015, 10:47 AM
Replies: 24
Views: 7,486
Posted By Rolepaul
Re: When work really hits home

Like you, I work in the industry, but as a consultant. Every day is something different for me. But at night, I get to focus on HER+ issues. Hopefully the monster can be helped by people like you...
Forum: her2group 05-06-2015, 10:38 AM
Replies: 20
Views: 9,348
Posted By Rolepaul
Re: Looking at Clinical Trials

MtnGirl,
CU Denver is running clinical trials that you might want to look at. Private mail me when you get to the Denver area as I just east of Boulder.
Paul
Forum: her2group 05-06-2015, 10:27 AM
Replies: 20
Views: 9,348
Posted By Rolepaul
Re: Looking at Clinical Trials

MtnGirl,
CU Denver is running clinical trials that you might want to look at. Private mail me when you get to the Denver area as I just east of Boulder.
Paul
Forum: her2group 04-21-2015, 02:49 PM
Replies: 6
Views: 3,290
Posted By Rolepaul
Re: Immunotherapy?

The pain in your back is from carrying all the weight of the hopes of a bunch of people.

Be proud to be one of the few brave enough to do this and healthy enough to know whether it will work.
Forum: her2group 04-21-2015, 02:47 PM
Replies: 60
Views: 27,304
Posted By Rolepaul
Re: Cancer in Spinal Fluid - given 6 months

dchips1 is one of the winners. She keeps getting the wrong of the stick and just goes on fighting. All I can say is she does this without having the support that many others do. Keep on fighting...
Forum: her2group 04-21-2015, 02:39 PM
Replies: 13
Views: 7,980
Posted By Rolepaul
Re: important-- turning her2+ Stage IV into chronic treatable disease

Immunotherapy is pretty expensive. It is very individualized in many cases. Treatments on the order of $100,000 for cell derived therapies using the patient's cells are common place. I asked for...
Forum: her2group 04-21-2015, 02:25 PM
Replies: 21
Views: 9,737
Posted By Rolepaul
Smile Re: TDM1 for HER2+ brain mets reocurrence?

Have your doctor call Dr. Monica Loghin at Brain and Spine Center of MD Anderson Cancer Center. I have not seen the articles yet. I would love to put them on this forum.
Forum: her2group 04-21-2015, 11:05 AM
Replies: 21
Views: 9,737
Posted By Rolepaul
Re: TDM1 for HER2+ brain mets reocurrence?

I get a can of Coke Zero or Diet Coke for every question I answer.
She does get accessed a lot, which means we train nurses how to access her at one of the Cancer Centers. Only three medical people...
Forum: her2group 04-21-2015, 09:19 AM
Replies: 21
Views: 9,737
Posted By Rolepaul
Re: TDM1 for HER2+ brain mets reocurrence?

Nina and others started at 40 mg weekly for a four week period. This lets the easy to kill cells die and causes less of need for steroids. Then bump it to 1.6 mg/kg to get the rest of the cells. ...
Forum: her2group 04-21-2015, 07:17 AM
Replies: 21
Views: 9,737
Posted By Rolepaul
Re: TDM1 for HER2+ brain mets reocurrence?

That case was actually run under Dr. Slamon. I contacted her mother in October of 2011. The woman has some short term memory issues, with the need to make a list of everything she needs to do for...
Forum: her2group 04-21-2015, 07:15 AM
Replies: 21
Views: 9,737
Posted By Rolepaul
Re: TDM1 for HER2+ brain mets reocurrence?

That case was actually run under Dr. Slamon. I contacted her mother in October of 2011. The woman has some short term memory issues, with the need to make a list of everything she needs to do for...
Forum: her2group 04-21-2015, 06:44 AM
Replies: 21
Views: 9,737
Posted By Rolepaul
Re: TDM1 for HER2+ brain mets reocurrence?

Short term studies that do not look at long term resolutions. TDM-1 systemic did slightly improve the Brain MRI haze, so there is some penetration, but prior to IT Herceptin there was steady...
Forum: her2group 04-20-2015, 10:12 PM
Replies: 13
Views: 7,980
Posted By Rolepaul
Re: important-- turning her2+ Stage IV into chronic treatable disease

That is very exciting. I would also like to hear if PDL1 or similar type of drugs are being paired with Herceptin to get better activity. Right now, Perjeta plus TDM-1 is over US$23,000 per...
Forum: her2group 04-20-2015, 10:06 PM
Replies: 235
Views: 303,977
Posted By Rolepaul
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Lani,
Actually, at the doses that were used with Nina and Carol, three of the deep brain patients had good results. It just means that steroids are needed to keep the swelling from causing...
Forum: her2group 04-20-2015, 09:27 AM
Replies: 235
Views: 303,977
Posted By Rolepaul
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Mario,
That is great news. Send my wishes to Carol.
We are still trying to get to Malta on a trip. I am halfway through working in Omaha during the week and driving home to Denver on the...
Forum: Herceptin / Tykerb 04-20-2015, 09:18 AM
Replies: 14
Views: 17,033
Posted By Rolepaul
Re: Herception

Less than 5% of the time there are heart issues of this type. If you are heavy, have prior heart issues, have high blood pressure, or high cholesterol, then there is a chance that this might occur. ...
Forum: her2group 04-20-2015, 08:37 AM
Replies: 20
Views: 9,348
Posted By Rolepaul
Re: Looking at Clinical Trials

With that much Xeloda, read the articles on Henna/lemon juice slurry to save your feet. Also, bag balm and udder cream with cloth gloves and socks at night.
I would recommend against the addition...
Forum: her2group 04-20-2015, 08:11 AM
Replies: 60
Views: 27,304
Posted By Rolepaul
Re: Cancer in Spinal Fluid - given 6 months

Karen, thanks for giving me a heads up. I am commuting from Denver to Omaha weekly for work. I got a private message and tried to help Saygoon get up to speed on some of the potential solutions to...
Forum: her2group 03-18-2015, 08:24 AM
Replies: 6
Views: 2,961
Posted By Rolepaul
Re: Mets Question

I do not think so. Tumor markers are a good way to check, PET scan, or Bone scan. But also, it can truly be unusual pain or discomfort in organ area. Brain/spine need an MRI scan. I
Forum: her2group 02-27-2015, 07:48 AM
Replies: 4
Views: 1,968
Posted By Rolepaul
Re: Treatment help required

Skin thickening and stiffening is due to the scarring of the surface. There are several creams for scarring that are on the market. I have used an Aloe mixture for my scars in the past with good...
Forum: her2group 02-27-2015, 07:45 AM
Replies: 235
Views: 303,977
Posted By Rolepaul
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Ask him to think about toptotecan as well. He can ask Dr. Loghin at MD Anderson Brain and Spine in Houston Texas.
Forum: her2group 02-27-2015, 07:36 AM
Replies: 235
Views: 303,977
Posted By Rolepaul
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

No, but I know what the protocol will be. That is part of something not public. It goes along with the Herceptin not tried at the higher doses prior to January 2012 for people like Carol and Nina. ...
Forum: her2group 02-26-2015, 10:25 AM
Replies: 235
Views: 303,977
Posted By Rolepaul
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Marvin, I would have them start the Pertuzumab at 40 mg for a few weeks and then go to the same level as you were having done with the IT Herceptin. Also, I wonder if you go back on the IT...
Forum: her2group 02-26-2015, 10:07 AM
Replies: 235
Views: 303,977
Posted By Rolepaul
Re: Intrathecal (IT) Herceptin (Trastuzumab) for brain mets (Leptomeningeal Metastase

Ask to have 0.4 mg of topotecan in 5 mls of sterile water added to the treatment. Do not use TDM-1 as the non-Herceptin part is too damaging. University of Southern California in Los Angeles is...
Showing results 26 to 50 of 363
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