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Search took 0.22 seconds; generated 80 minute(s) ago. Search: Posts Made By: Lani
Forum: her2group 02-07-2015, 11:08 AM
Replies: 4
Views: 3,117
Posted By Lani
Thumbs up Herceptin (lovingly referred to here as "Vitamin H") may become a widespread tool for

drug-delivery, increasing drug duration of action as body takes much longer to degrade hormones and other medications "fused" to herceptin. May even lead to alonger acting form of insulin!!


...
Forum: her2group 02-07-2015, 11:07 AM
Replies: 0
Views: 1,462
Posted By Lani
Thumbs up Herceptin (lovingly referred to here as "Vitamin H") may become a widespread tool for

drug-delivery, increasing drug duration of action as body takes much longer to degrade hormones and other medications "fused" to herceptin. May even lead to alonger acting form of insulin!!
...
Forum: her2group 01-29-2015, 01:28 PM
Replies: 11
Views: 3,923
Posted By Lani
Re: already approved antibiotics to the rescue?? schoolgirls innocent question may ha

I think you might have misheard

It is possible that breast cancer might be caused by a virus-- many head and neck and cervical cancers are-- but antibiotics are not effective against viruses

If...
Forum: her2group 01-28-2015, 11:31 PM
Replies: 11
Views: 3,923
Posted By Lani
Thumbs up already approved antibiotics to the rescue?? schoolgirls innocent question may have

opened new line of inquiry in cancer treatment

Schoolgirl comment points to antibiotics as new cancer treatments
[University of Manchester (UK)]
A way to eradicate cancer stem cells, using...
Forum: her2group 01-21-2015, 05:22 PM
Replies: 3
Views: 2,277
Posted By Lani
Re: INCREDIBLE MILESTONE--trial of less toxic regimen in <3cm her2+ early bc ~100% 3y

http://www.dana-farber.org/Newsroom/News-Releases/combined-therapy-can-reduce-chance-of-recurrence-in-women-with-small-her-2-positive-breast-tumors.aspx
Forum: her2group 01-20-2015, 05:26 PM
Replies: 3
Views: 2,277
Posted By Lani
Thumbs up INCREDIBLE MILESTONE--trial of less toxic regimen in <3cm her2+ early bc ~100% 3yrdfs

dfs=invasive disease free survival

from Med Page Today

Oncology/Hematology 01.07.2015

Less Toxic Breast Ca Regimen Deemed Successful

Study finds 98.7% rate of 3-year freedom from...
Forum: her2group 01-18-2015, 12:04 PM
Replies: 12
Views: 3,238
Posted By Lani
Re: Neuropathy and shoes

Have you tried crocs? Both the classic clog-like style and many of their other more"fun" styles. Materiaal is a bit like rubberized egg white so very"forgiving"

Also authentic scandinavian wooden...
Forum: her2group 01-07-2015, 03:18 PM
Replies: 0
Views: 1,650
Posted By Lani
panel recomends fda approve 1st biosimilar

...herceptin should finally get cheaper once a biosimiilar for herceptin is made & applies for , gets fda approval sometime in the future...
...
Forum: Herceptin / Tykerb 01-04-2015, 02:47 PM
Replies: 25
Views: 31,328
Posted By Lani
Re: lingering side effects after finishing herceptin

By starting a separate thread from the Please list your side effects on herceptin, real and imagined, you have made it harder for, someday, someone to try to utilize the info for some "post marketing...
Forum: her2group 12-19-2014, 11:22 AM
Replies: 12
Views: 4,787
Posted By Lani
Re: Is THIS the reason adding herceptin to chemo only improves OS by 40%?

linn65--they only look for what is requested by the doctor ordering the pathology examination with report and only with the means requested

eg, if IHC (immunohistochemistry) is requested and only...
Forum: her2group 12-18-2014, 12:59 AM
Replies: 6
Views: 2,969
Posted By Lani
Re: THIS MAY BE BIG: new monoclonalantibody-peptide conjugate crosses blood-brainbar

bringing this up so ROLEPAUL can see it if he missed it
Forum: her2group 12-18-2014, 12:45 AM
Replies: 12
Views: 4,787
Posted By Lani
Re: Is THIS the reason adding herceptin to chemo only improves OS by 40%?

hyaluronan is like glue in the space between cells and surrounds her2+ breast cancer cells in about 60% of her2+ tumors

translation of the rest:

Despite tremendous progress in cancer...
Forum: her2group 12-17-2014, 02:32 AM
Replies: 12
Views: 4,787
Posted By Lani
Lightbulb Is THIS the reason adding herceptin to chemo only improves OS by 40%?

I had assumed that de novo resistance to herceptin (initial p95 truncated receptors, presence of complex mucin which prevented herceptin from approaching the receptor, inadequate immune system...
Forum: her2group 12-16-2014, 03:42 AM
Replies: 3
Views: 2,032
Posted By Lani
Re: Anyone at SABCS?

I attended

They did not video, but recorded audio and slides

They said it would be available in about a month--don't know if that is just for atendees and when non attendee availability will...
Forum: her2group 12-16-2014, 01:33 AM
Replies: 44
Views: 12,966
Posted By Lani
Thumbs up early Christmas present--10 yr overall & bc specific survival results just published!

from the two key trials which led to approval of herceptin for adjuvant use.

And cardiac problems now estimated only at 3% with majority of these reversible

RELEASE DATE: 15-Dec-2014
[ Print...
Forum: her2group 12-14-2014, 02:22 PM
Replies: 6
Views: 2,969
Posted By Lani
Lightbulb THIS MAY BE BIG: new monoclonalantibody-peptide conjugate crosses blood-brainbarrier

in mice

Let's get the clinical trial started soon!

Mol Cancer Ther. (http://www-ncbi-nlm-nih-gov.laneproxy.stanford.edu/pubmed/25492620#) 2014 Dec 9. [Epub ahead of print]
ANG4043, a Novel...
Forum: her2group 12-11-2014, 12:13 AM
Replies: 0
Views: 1,847
Posted By Lani
at San Antonio--for all those fighting leptomeningeal metastases...

At the end of one of the pre-conference educational sessions brief mention was made of a new formulation of herceptin, especially conceived for intrathecal treatment

If I hear more, I will let you...
Forum: her2group 12-05-2014, 12:54 AM
Replies: 0
Views: 2,637
Posted By Lani
Arrow for those choosing between whole brain rad therapy and stereotactic (gamma or cyberkn

ife) the following, fresh off the press, may help in your deliberations. Obviously, only a radiation therapist with expertise can advise you as to whether your tumor is "limited" and whether there...
Forum: her2group 12-05-2014, 12:49 AM
Replies: 21
Views: 9,603
Posted By Lani
Re: TDM1 for HER2+ brain mets reocurrence?

thanks rhondalea

I have always been particularly lousy @ providing links (although I have improved a bit over the past 9+yrs I have been posting)--thank goodness you are there to make up for my...
Forum: her2group 12-04-2014, 06:42 PM
Replies: 21
Views: 9,603
Posted By Lani
Re: TDM1 for HER2+ brain mets reocurrence?

Clin Breast Cancer. 2014 Oct 19. pii: S1526-8209(14)00223-7. doi: 10.1016/j.clbc.2014.10.003. [Epub ahead of print]

Brain Metastasis and Response to Ado-Trastuzumab Emtansine: A Case Report and...
Forum: her2group 12-04-2014, 05:21 PM
Replies: 1
Views: 2,825
Posted By Lani
Thumbs up highly recommended article by M. Scaltriti re predicting those who respond best

to herceptin + lapatinib combination, theorizing how the article's findings could identify those who could be treated with the antiher2 combination without chemo.

Still a work in progress, the...
Forum: her2group 12-03-2014, 12:24 PM
Replies: 0
Views: 2,131
Posted By Lani
research shows NSAIDs my prevent repopulation of tumors by cancer stem cells between

chemo doses--this finding may explain another way metronomic chemotherapy (giving much, much smaller doses but every day) works ie, no time for PGE2 rebound

3-Dec-2014
[ Print | E-mail ] Share...
Forum: her2group 12-02-2014, 10:52 AM
Replies: 0
Views: 2,322
Posted By Lani
Lightbulb reservatrol suppresses her2+ bc cell proliferation by inhibiting FASN signalling--pre

dlinical--so don't ask me the correct dose of your supplement to take,

It is unclear it holds in humans or what the dose should be. With some things, the effect of too much is the opposite of the...
Forum: her2group 12-02-2014, 10:41 AM
Replies: 6
Views: 5,418
Posted By Lani
Thumbs up Simple cheap drugs already approved vs. osteoporosis may prevent, reverse her2+breast

cancer

http://www.pnas.org/content/early/2014/11/26/1421422111

Widely Used Osteoporosis Drugs May Prevent Breast, Lung and Colon Cancers

NEW YORK – December 1, 2014 /Press Release/ –– ...
Forum: her2group 12-01-2014, 12:21 AM
Replies: 8
Views: 7,364
Posted By Lani
Thumbs up new bc vaccine from Washington Univ (not UNIV OF WASHINGTON) PROMISING

BASED ON DIRECTING IMMUNE SYSTEM AGAINST MAMMOGLOBIN A , WHICH VAST MAJORITY OF BCs have (in contrast to her2, which a small --but very important-- minority have amplified)

1-Dec-2014
[ Print |...
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