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-   -   Combined CDK4/6 and EGFR inhibition improves pancreatic cancer therapy (https://her2support.org/vbulletin/showthread.php?t=71772)

News 03-13-2026 12:54 PM
Combined CDK4/6 and EGFR inhibition improves pancreatic cancer therapy
 
Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare.

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