Intestinal tumour chemoprevention with the antioxidant lipoic acid stimulates the gro
 

<dl class="AbstractPlusReport"><dt class="head">1: Eur J Cancer. 2008 Nov;44(17):2696-704. Epub 2008 Oct 14.http://www.ncbi.nlm.nih.gov/corehtml...PubMedLink.gif <script language="JavaScript1.2"><!-- var Menu18926695 = [ ["UseLocalConfig", "jsmenu3Config", "", ""], ["Compound (MeSH Keyword)" , "window.top.location='/sites/entrez?Db=pccompound&DbFrom=pubmed&Cmd=Link&LinkNa me=pubmed_pccompound_mesh&LinkReadableName=Compoun d%20(MeSH%20Keyword)&IdsFromResult=18926695&ordina lpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_R esultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstrac tPlus' ", "", ""], ["GENSAT" , "window.top.location='/sites/entrez?Db=gensat&DbFrom=pubmed&Cmd=Link&LinkName=p ubmed_gensat&LinkReadableName=GENSAT&IdsFromResult =18926695&ordinalpos=1&itool=EntrezSystem2.PEntrez .Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel. Pubmed_RVAbstractPlus' ", "", ""], ["Gene" , "window.top.location='/sites/entrez?Db=gene&DbFrom=pubmed&Cmd=Link&LinkName=pub med_gene&LinkReadableName=Gene&IdsFromResult=18926 695&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubme d.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed _RVAbstractPlus' ", "", ""], ["HomoloGene" , "window.top.location='/sites/entrez?Db=homologene&DbFrom=pubmed&Cmd=Link&LinkNa me=pubmed_homologene&LinkReadableName=HomoloGene&I dsFromResult=18926695&ordinalpos=1&itool=EntrezSys tem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_Dis coveryPanel.Pubmed_RVAbstractPlus' ", "", ""], ["Nucleotide (RefSeq)" , "window.top.location='/sites/entrez?Db=nuccore&DbFrom=pubmed&Cmd=Link&LinkName= pubmed_nuccore_refseq&LinkReadableName=Nucleotide% 20(RefSeq)&IdsFromResult=18926695&ordinalpos=1&ito ol=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPane l.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus' ", "", ""], ["Nucleotide (Weighted)" , "window.top.location='/sites/entrez?Db=nuccore&DbFrom=pubmed&Cmd=Link&LinkName= pubmed_nuccore_weighted&LinkReadableName=Nucleotid e%20(Weighted)&IdsFromResult=18926695&ordinalpos=1 &itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Results Panel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus' ", "", ""], ["Protein (RefSeq)" , "window.top.location='/sites/entrez?Db=protein&DbFrom=pubmed&Cmd=Link&LinkName= pubmed_protein_refseq&LinkReadableName=Protein%20( RefSeq)&IdsFromResult=18926695&ordinalpos=1&itool= EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.P ubmed_DiscoveryPanel.Pubmed_RVAbstractPlus' ", "", ""], ["Protein (Weighted)" , "window.top.location='/sites/entrez?Db=protein&DbFrom=pubmed&Cmd=Link&LinkName= pubmed_protein_weighted&LinkReadableName=Protein%2 0(Weighted)&IdsFromResult=18926695&ordinalpos=1&it ool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPan el.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus' ", "", ""], ["Substance (MeSH Keyword)" , "window.top.location='/sites/entrez?Db=pcsubstance&DbFrom=pubmed&Cmd=Link&LinkN ame=pubmed_pcsubstance_mesh&LinkReadableName=Subst ance%20(MeSH%20Keyword)&IdsFromResult=18926695&ord inalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubme d_ResultsPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbst ractPlus' ", "", ""], ["Taxonomy via GenBank" , "window.top.location='/sites/entrez?Db=taxonomy&DbFrom=pubmed&Cmd=Link&LinkName =pubmed_taxonomy_entrez&LinkReadableName=Taxonomy% 20via%20GenBank&IdsFromResult=18926695&ordinalpos= 1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_Result sPanel.Pubmed_DiscoveryPanel.Pubmed_RVAbstractPlus ' ", "", ""], ["UniGene" , "window.top.location='/sites/entrez?Db=unigene&DbFrom=pubmed&Cmd=Link&LinkName= pubmed_unigene&LinkReadableName=UniGene&IdsFromRes ult=18926695&ordinalpos=1&itool=EntrezSystem2.PEnt rez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPan el.Pubmed_RVAbstractPlus' ", "", ""], ["GEO Profiles" , "window.top.location='/sites/entrez?Db=geo&DbFrom=pubmed&Cmd=Link&LinkName=pubm ed_geo&LinkReadableName=GEO%20Profiles&IdsFromResu lt=18926695&ordinalpos=1&itool=EntrezSystem2.PEntr ez.Pubmed.Pubmed_ResultsPanel.Pubmed_DiscoveryPane l.Pubmed_RVAbstractPlus' ", "", ""], ["LinkOut", "window.top.location='/sites/entrez?Cmd=ShowLinkOut&Db=pubmed&TermToSearch=1892 6695&ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubm ed.Pubmed_ResultsPanel.Pubmed_DiscoveryPanel.Pubme d_RVAbstractPlus' ", "", ""] ] --></script>Links
</dt><dd class="abstract"> Intestinal tumour chemoprevention with the antioxidant lipoic acid stimulates the growth of breast cancer.

<!--AuthorList-->Rossi C, Di Lena A, La Sorda R, Lattanzio R, Antolini L, Patassini C, Piantelli M, Alberti S.
Animal Care Unit, Consorzio Mario Negri Sud, SM Imbaro (Chieti), Italy.
OBJECTIVE: Breast and intestinal cancers chemoprevention would significantly impact on cancer care. Hence, we assessed the chemopreventive efficacy of the antioxidant lipoic acid (LA) in mice overexpressing a wild-type Her2/neu, as an animal model of breast cancer, and in APCmin mice for intestinal cancer. METHODS: Mice were randomised at weaning, and were treated with LA for lifetime. Tumour incidence, growth rate and histopathology were analysed on an individual tumour basis. RESULTS: LA efficiently chemoprevented tumour appearance in APCmin mice. Strikingly, though, LA doses, that were chemopreventive in APCmin mice (> or = 300 microg/day), increased breast cancer growth in Her2/neu mice. Even in experimental groups, where LA overall reduced tumour risk (80 microg/day), LA consistently stimulated the growth rate of established breast tumours. Breast and colon tumours incidence was unaffected by LA, indicating no significant impact of LA on tumour initiation and no protection from mutations driving tumour progression. CONCLUSIONS: Stimulation of breast cancer growth and inhibition of intestinal tumours by LA indicate that diverse growth control mechanisms are modulated by LA in different organs. Concern is raised about the use of LA for cancer chemoprevention.
PMID: 18926695 [PubMed - indexed for MEDLINE
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