article on HER2/14-3-3 combo
 

http://www.cancercompass.com/cancer-...m?c=1004:5:1:2

Overexpressed Protein Converts Noninvasive Breast Cancer Into Invasive Disease

NewsRx.com


[The researchers show that 14-3-3(zeta) teams with the oncoprotein ErbB2, also known as HER2, in a two-hit process to convert normal mammary cells to invasive cancer cells.
In addition to identifying this key step in EMT, Yu notes the findings also provide:



A biomarker in 14-3-3(zeta) to identify high-risk patients for more aggressive treatment before their noninvasive breast cancer converts to invasive disease.


New therapeutic targets among the components of the molecular pathway launched by 14-3-3(zeta). Some drugs already aim at these targets, Yu said.


A solution to a puzzling mystery about how a subset of non-invasive breast cancer with excessive presence of a ErbB2/HER2 develops into invasive breast cancer.]


(more at the link above)