Sounds like this is a (modified) Herpes virus you might WANT to get!!!!
Modified Herpes Virus Shows Promise Against Metastatic Melanoma
May 28 - A gene-modified, immune-enhanced herpes simplex type 1 virus has shown promising activity against metastatic melanoma in a phase II study reported Wednesday at the 12th annual meeting of American Society of Gene Therapy in San Diego. A pivotal phase III trial of the modified virus -- OncoVEX GM-CSF (BioVex, Woburn, MA) -- involving 360 melanoma patients is underway. "We believe OncoVEX GM-CSF has a local oncolytic effect, selectively replicating in and directly killing tumor cells, and an immune-stimulating effect," which destroys un-injected metastatic deposits, study presenter Dr. Neil N. Senzer of the Mary Crowley Cancer Research Center, Dallas, Texas, said in a telephone interview with Reuters Health. In the study, 50 patients with inoperable stage IIIc/IV malignant melanoma, most of whom were progressing after having failed prior therapy, received OncoVEX GM-CSF by injection into tumor sites every 2 weeks for 26 weeks. "In an intention-to-treat analysis of all 50 patients, we had 8 patients with complete response and 5 with partial response," Dr. Senzer told Reuters Health. The overall response rate was therefore 26%, "with 58% still alive at 1 year and 52% alive through 2 years, which is pretty exciting for this group of patients," the investigator added. "And when you look at patients with complete response, we had 92% survival at 1 year in that group and 87% going on to 2 years; so very provocative initial data." Patients with stage IV melanoma have a median survival of 6 months. Overall median survival in the current study was 16 months. Dr. Senzer also said preliminary clinical studies indicate that OncoVEX GM-CSF is also active against other tumor types, including breast cancer, head and neck cancer, and pancreatic cancer. The treatment has minimal side effects, "mostly flu-like symptoms," the researcher noted. |
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