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- - AI Booster? (https://her2support.org/vbulletin/showthread.php?t=38236)

Jean	03-02-2009 09:33 AM

AI Booster?

http://www.mamm.com/news.php?&newsid=4

As those of us who are on AI treatment are concerned about reaching a point where the AI stops working...here is some interesting research.

Each day we continue to get a little bit closer...

Regards,
jean

PinkGirl

03-02-2009 10:05 AM

I don't understand this. I didn't think that AI's did anything to cancer
cells. I thought aromataze was an enzyme that converted androgens to
estrogens ... the androgens that are in our fat cells ... Does this mean
that the AI no longer inhibits this conversion?

Jean	03-02-2009 10:24 AM

Hi Pinkgirl,
I think (not sure) from what I read in this article that the drug Nexavar is assisting the AI to function.

The addition of Nexavar to Arimidex helps restore sensitivity to Arimidex among women with breast cancer.

This is first article I have seen anything on AI and this situation...
Additional information...

http://ww5.komen.org/ExternalNewsArt...x?newsID=42702

regards,
jean

Becky

03-02-2009 10:47 AM

So basically a multiple kinase inhibitor (Tykerb is a tyrosine kinase inhibitor) is used to help block other pathways that have overridden the estrogen receptor. Therefore, the AI is still working but other mechanisms have taken over the "grow, grow, grow" which is really the true essence of any drug resistance. It is not that the drug does not work, it is that the cancer either changes or has multiple pathways to use to grow (from the beginning).

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