Herceptin + Tykerb - anyone?
 

Hi,

With Lani's recent post of Dr. Osborne's Her2 targeted therapy combination trial, I was wondering if there are any individuals on the board who are currently being treated with Herceptin + Tykerb.

There are a number of current ongoing clinical trials of the combination and I believe there were a couple of individuals with oncologists that prescribed the combination off-label.

Anyone? It would be great to hear how you are doing.

Thanks in advance for any responses.

Regards,

Amy

Hi Amy! My wife, Nicola was one of the first to sign up for a clinical trial of Tykerb(Lapatinib), Taxol, and Herceptin. They wanted to see the effects of the Lapatinib/Taxol combo. She did great for 15 months, and then progressed slightly, so they had to pull her from the clinical trial. Tykerb is one of the few chemo. drugs that is effective through the blood/brain barrier, so it seems that, from my layman's point of view, that your onc. is on the ball. Common Tykerb side-effects include diarrhea, and common Herceptin side-effects include runny nose, coughing, nosebleeds (sometimes). Many women on this site have alot more to add than I do, and I'm sure they will chime in. Andi has been on herceptin for 10 years! I'm praying for you, Amy, Love, Bill

Herceptin tykerb too
 

Hi Amy-
I've been on Herceptin Tykerb combo for about 8 or 9 weeks.

I don't have any scan reports but I am doing fine on that combo regarding side effects. -- Flori

Thanks, Flori.

I looked back in your posts but didn't see the answer to this: Are you in a clinical trial or is your doctor giving you the combination off-label? Thanks again for your response.

Since I was on tykerb xeloda we continued with the tykerb and have added herceptin. I think that once a drug is approved they don't usually take it away from you but who knows with the insurance.
Best
Flori

ask your doctor about the herceptin-dm1 trial.. many on this board are on this clinical trial..

http://www.clinicaltrials.gov/ct2/sh...ow_locs=Y#locn

they have both a once a week.. phase 1 trial and once every 3 week trial..phase 2

Amy,

I was on the combo and it held off progression for about 6 months. Then markers began to rise and scans confirmed progression in bones. Now I am back on Gemzar and Herceptin.

Good Luck, Carolyn

carolyns.. have you talked to your md about the tras-dm1 to replace the herceptin..

one of genentech's lead trial docs shani modi gave this presentation last sept 07..

http://www.medscape.com/viewarticle/570430

the tras-dm1 starts around slide 15..

run to live..

here are the florida sites.

<TABLE cellSpacing=0 cellPadding=2 border=0><TBODY><TR><TD class=header3 noWrap colSpan=5>United States, Florida</TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=2>Bay Area Oncology </TD><TD class=spacer><TD class=header3 noWrap>Recruiting</TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=5> Tampa, Florida, United States, 33607 </TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=5> Contact: Julie Hahn 813-875-2300 ext 28 jhahn@bayareaoncology.com </TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=2>Florida Cancer Care </TD><TD class=spacer><TD class=header3 noWrap>Recruiting</TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=5> Davie, Florida, United States, 33328 </TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=5> Contact: Joel Espinoza 954-262-7606 crc@flcancercare.com </TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=2>Gulfcoast Oncology Associates </TD><TD class=spacer><TD class=header3 noWrap>Recruiting</TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=5> Saint Petersburg, Florida, United States, 33705 </TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=5> Contact: Margie Blasek 727-821-0017 mblazek@gulfcoastoncology.com </TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=2>Hem/Onc Assoc - Treasure Coast </TD><TD class=spacer><TD class=header3 noWrap>Recruiting</TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=5> Port St Lucie, Florida, United States, 34952 </TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=5> Contact: Christine Baker-Gerdes 772-408-5159 cgerdes@hemoncfl.com </TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=2>Lynn Cancer Institute - West </TD><TD class=spacer><TD class=header3 noWrap>Recruiting</TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=5> Boca Raton, Florida, United States, 33428 </TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=5> Contact: Jacqueline Perez 561-883-7554 jperez@lrccw.com </TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=2>Mayo Clinic </TD><TD class=spacer><TD class=header3 noWrap>Recruiting</TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=5> Jacksonville, Florida, United States, 32224 </TD></TR><TR><TD class=spacer><TD class=body3 noWrap colSpan=5> Contact: Leandra Rigby 904-953-6119 Rigby.Leandra@Mayo.Edu </TD></TR></TBODY></TABLE>