Anyone famililiar w/ this...
 

"Multivariate analysis of expression of the microtubule-associated protein, tau, predicts improved progression free and overall survival in patients with metastatic HER-2-negative breast cancers treated with docetaxel and vinorelbine plus filgrastim."

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"High level analysis of genomic data reveals complex predictors of response to trastuzumab (T) and chemotherapy for early stage breast cancer"


There will be a discussion at ASCO on 6/3/05 on this

Rhonda

here are two articles on it:
 

Wagner P, Wang B, Clark E, Lee H, Rouzier R, Pusztai L. Related Articles, Links
Microtubule Associated Protein (MAP)-Tau: a novel mediator of paclitaxel sensitivity in vitro and in vivo.
Cell Cycle. 2005 Sep;4(9):1149-52. Epub 2005 Sep 17.
PMID: 16103753 [PubMed - in process]
6: Rouzier R, Rajan R, Wagner P, Hess KR, Gold DL, Stec J, Ayers M, Ross JS, Zhang P, Buchholz TA, Kuerer H, Green M, Arun B, Hortobagyi GN, Symmans WF, Pusztai L. Related Articles, Links
Microtubule-associated protein tau: a marker of paclitaxel sensitivity in breast cancer.
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8315-20. Epub 2005 May 24.
PMID: 15914550 [PubMed - indexed for MEDLINE]

Just another marker like TOPO II and HER2 and PHEN that may predict a positive response to treatment with a certain drug. This is the way of the future given unneccessary side effects and high drug costs.

Al