I need a path report 101 ???
 

Hi,

I just got my path report from my core biopsy and wonder if anyone can help me understand what it all means.It reads as follows:

Invasive ductal carcinoma, poorly differentiated, Nottingham scores:2 (tubular formation) +3 (nuclear grade) +3 (mitotic activity)=8/9, grade 3, with focal necrosis.
- INVOLVING 3 OUT OF 3 CORDS.
- NO DIFINITIVE LYMPHOVASCULAR INVASION SEEN

ER negative (0%)
PR negative (0%)
Her2/neu positive (2+/3+)
K167 positive (90%)
P53 positive (90%)

FISH test: The ratio of Her-2 to chromosome 17 centomere is 5.20.


I know what er/pr and her2 are and what they mean but what are the k167 and p53?
also what are they reffering to when they say 3 out of 3 cords?
and how good or bad is a 5.20 ratio on the fish?

If anyone can give me some help with this I would greatly appreciate it.

Thanks a bunch, Alice

Here is a link to a good guide on pathology reports:

http://www.breastcancer.org/pathology_report.pdf


Regards
Joe

Joe,


That's an excellent site that explains the pathology report.

Thank you Joe that site is verry helpfull.

Alice

Hi,


Your path report says that you have an aggressive type of tumor, the negative ER/PR indicates the tumor will not respond to hormone inhibiting drugs such as tamoxifen, the HER2 positive indicates a good chance of favorable response to Herceptin (with chemo) and you should endorse a strong treatment plan.

I thought by interpretting the mythical words into common English, you would get the main message.

There are many effective ways to treat breat cancers of various type. Hope you find a good onc and a successful fight. We are all behind you to support the battle.

Ann

Hi, Run a search on this site. I know there was a thread where people discussed their fish scores in the last few months. I have no idea about the cords. Maybe coordinates? Good Luck. BB