Question about Path Report
 

Hi Laides,

I have a question, below is my path report, can someone tell me what the following means:

Estrogen and progesterone receptor results are scored as a percentage of positively stained nuclei as followes:

Positive - >10% of tumor cell nuclei
low positive >1% to <10% of tumor cell nuclei
Negative <1% of tumor cell nuclei


Her2/neu indeterminate (2+) by immunoshistochemisty, I did have the fish test, but don't have that report.

Does this mean I have low er+ and pr+

Than a wrote some number doen by my her2/neu report, it says 2.7 and 17, totally forgot what that was.

Any help?

Just curious, I have already done 4 A/C and 12 taxol/herceptin, start rads in Jan, then we will see what is next, depending on if i'm in menopause.

Thanks
Randi

Hi Randi,

The 2.7 is probably what your IHC score was. Anything over 2 usually goes on to have a FISH test done. At least that was how it worked in my sitution. The 17, someone else can help you with, I think it has to do with how many strands of DNA are attached or something that meant nothing to me. Sorry.
On my report for er/pr statis, it says specifically what the percentages are for each.
I think you maybe looking at ranges, does it say favorable or unfavorable or borderline on that same page? You might want to check with your onc. about that. I would think they would be able to give you a specific number. Best to you Randi.

Randi
I am fairly certain that what you are seeing is just a definition of what the results mean and not any results.
Positive - >10% of tumor cell nuclei: This means that if the results are above (or greater than) 10% then it is positive.

low positive >1% to <10% of tumor cell nuclei: This means that the results are low positive if they are between 1% and 10%.

Negative <1% of tumor cell nuclei: and this means if the results are below 1% they are negative.

I cannot respond to your qustions about HER2 as I am real dummy about what that means.
Hope this helps.

Marlys

Hi there

I actually do testing - the last reply was correct - you are just looking at reference ranges not your results.

The other results (2.7 / 17) may be your FISH results but is not clear by what you have written. Does it say anything else?