Steph, I believe I understand what you are saying regarding the stats but I will continue to do all that I (we) can, that is medically responsible, to sway the odds more in her favor. I do not believe that it has to be a case of when! My wife was found to be +2-+3 according to IHC and she was FISH positive. I'm sorry that you were not able to take the herceptin before the mets came but I'm glad it has proven helpful for you now. I'm also thankful that my wife has access to it now and I pray that it makes the difference for her. Thanks for the words and the prayers. My thoughts and prayers, Eric