HER2 Support Group Forums

HER2 Support Group Forums (https://her2support.org/vbulletin/index.php)
-   Articles of Interest (https://her2support.org/vbulletin/forumdisplay.php?f=31)
-   -   Scientists Identify 10 Different Types of Breast Cancer (https://her2support.org/vbulletin/showthread.php?t=54067)

Christine MH-UK 04-18-2012 01:37 PM

Scientists Identify 10 Different Types of Breast Cancer
Interesting Story from Business Week on why this study may help to improve clinical trials:

More detail from Cancer Research UK, which funded the study:

Ellie F 04-19-2012 10:40 AM

Re: Scientists Identify 10 Different Types of Breast Cancer
Thanks for posting. Heard this on the news yesterday and so was very interested to understand more about how it broke down.

AlaskaAngel 04-20-2012 11:25 AM

Re: Scientists Identify 10 Different Types of Breast Cancer
Thank you very much, Christine MH-UK.


gdpawel 05-04-2012 09:57 PM

How Long Until Progress Reaches the Clinic?
I like what Dr. Elaine Schattner had to say about this. The mainstay of treatment would be a cocktail of drugs, by mouth, like patients take for hepatitis C, tuberculosis or AIDS.


Cocktails have become standard treatment in many oncological protocols: concoctions of two or more powerful cytotoxic agents which supposedly will attack the tumor in different ways. The ability of various agents to kill tumor and/or microvascular cells (anti-angiogenesis) in the same tumor specimen is highly variable among the different agents. There are so many agents out there now, doctors have a confusing array of choices. They don't know how to mix them together in the right order.

A diagnosis of AIDS was a death sentence until the advent of drug cocktails in the 1990s, which helped patients suppress the disease indefinitely. Now researchers say a similar combination strategy may change the course of cancer.

The application of synergy analyses (drug cocktails) may represent one of the most important applications of the functional cytometric profiling platform, enabling the exploration of both anticipated and unanticipated favorable interactions. Equally important may be the capacity to study drug antagonism wherein two effective drugs counteract each others’ benefits. This phenomenon, characterized by the whole being less than the sum of the parts, represents a major pitfall for clinical trialists who simply combine drugs “because they can.”

These analyses are revolutionizing the way newer classes of drugs are applied and has the potential to accelerate drug development and clinical therapeutics. Good outcomes require good drugs, but better outcomes require good combinations. Intelligent combinations are a principle focus of the functional cytometric profiling platform. It strives to identify the best outcomes for patients (not populations of patients).

Arnold Glazier, M.D., former Oncology Fellow at Johns Hopkins, said in his book Cure: Scientific, Social and Organizational Requirements for the Specific Cure of Cancer," the consistent and specific cure or control of cancer will require multiple drugs administered in combination targeted to abnormal patterns of normal cellular machinery that effect or reflect malignant behavior. Finding the 'patterns' of malignant cells and developing a set of 5 to10 drugs in order to cure or control cancer."


Rich66 05-04-2012 10:47 PM

Re: Scientists Identify 10 Different Types of Breast Cancer
Better than previous suggestions of "thousands". But..idealist I am, hope there can be an upstream common target/achilles heel not only within a given cancer, but across cancer types. No idea if it will play out as such..but Genspera's G202 is one of few that purports to approach cancer at a level beyond the myriad permutations that keep labs busy but progress limited.
But hey..if a manageable rotation of 5 to 10 drugs can suffice..I'm all in.
Worth noting that viral approaches, including one of the early AIDS drugs, Viracept/Nefilnavir, have been showing efficacy in various cancers. Maybe we should be trying those AIDS "cocktails" on cancer.

gdpawel 05-05-2012 06:43 AM

Re: Scientists Identify 10 Different Types of Breast Cancer
Dr. Phillip Dennis and colleagues did exactly that: they took existing HIV protease inhibitor drugs and tested 6 of them against cancer cell lines derived from 9 different human tumor types and found that three of the drugs (ritonavir, nelfinavir and saquinavir) reduced the growth of 60 of those cell lines.

In the laboratory, nelfinavir or Viracept, a first generation speific protease inhibitor designed for HIV appeared most potent (Autophagy 4(1):107-9, 2008).


Tumor-Cell Death, Autophagy, and Immunity


All times are GMT -7. The time now is 01:09 PM.

Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2021, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007 - 2021