Clinical impact of differential risk stratification by breast cancer index (BCI) vers
I've edited slightly to make this more readable - 'lizbeth
Clinical impact of differential risk stratification by breast cancer index (BCI) versus recurrence score (RS) in HR+ early-stage breast cancer: A TransATAC study. Abstract No: 532 Attend this session at the 2014 ASCO Annual Meeting! Session: Breast Cancer - HER2/ER <hr width="40%">Type: Poster Highlights Session Time 1: Sunday June 1, 8:00 AM to 11:00 AM Location 1: E354b Time 2: Sunday June 1, 11:30 AM to 12:45 PM <table border="0" cellpadding="0" cellspacing="0"><tbody><tr><td>http://abstracts.asco.org/144/resour.../itinerary.gif</td><td>Personalize your Meeting experience with a suggested or customized itinerary!</td></tr></tbody></table>Location 2: E Arie Crown Theater Author(s): Ivana Sestak, Yi Zhang, Catherine A. Schnabel, Brock Schroeder, Mark Erlander, Paul E. Goss, Jack M. Cuzick, Mitchell Dowsett, Dennis Sgroi; Queen Mary, University of London, London, United Kingdom; bioTheranostics, Inc., San Diego, CA; Trovagene, San Diego, CA; Massachusetts General Hospital Cancer Center, Boston, MA; Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, London, United Kingdom; The Royal Marsden NHS Foundation Trust, London, United Kingdom; Massachusetts General Hospital, The Avon Foundation, Boston, MA Abstract Disclosures Abstract: Background: Breast cancer index (BCI) is a genomic signature that significantly predicts risk of both early (0-5y) and late (5-10y) distant recurrence (DR) in HR+, LN- breast cancer. Previous results from the TransATAC study showed that both breast cancer index (BCI) and Oncotype Dx RS added significant prognostic information for 10y DR risk. Here, pre-defined risk stratification with breast cancer index (BCI) vs recurrence score (RS) and its potential clinical impact were comparatively evaluated. Methods: 665 HR+, LN- patients were examined. BCI and recurrence score (RS) risk groups were determined using pre-defined clinical cut-points. Kaplan-Meier estimates of 10y risk of DR and log-rank tests were used to examine cross-stratification between breast cancer index (BCI) and recurrence score (RS). Likelihood Ratio (LR) tests were used to quantitate relative prognostic information beyond CTS. Results: breast cancer index (BCI) re-stratification of the RS-Intermediate (RS-I) and RS-Low (RS-L) groups significantly impacted risk of 10y DR (P=0.003 and P<0.001), whereas RS did not significantly re-stratify BCI risk prediction (Table). breast cancer index (BCI) identified a small subset (20 pts in RS-L) with a high risk of DR (23.3%). Furthermore, breast cancer index (BCI) identified a large (95 pts in RS-I) and smaller (34 pts in RS-I) subset with 7.1% and 27.8% 10y DR risk, respectively. BCI added significant prognostic information beyond CTS+ RS (p=0.0009), whereas recurrence score (RS) did not provide additional prognostic information beyond CTS+ breast cancer index (BCI) (p=0.1). Conclusions: In this retrospective analysis evaluating individualized risk stratification, breast cancer index (BCI) identified subsets of RS-L and RS-I LN- patients with significant and clinically distinct rates of DR. Breast cancer index (BCI) identified a small subset of RS-L and RS-I LN- patients that would potentially benefit from additional therapy. <table class="mtgabstract"><caption class="mtgabstract-table-title">Risk stratification and 10-year distant recurrence rates (%).</caption> <thead class="mtgabstract"> <tr> <th class="align-left" colspan="2" rowspan="2">No. of patients </th> <th class="border-bottom-broken align-middle" colspan="3">BCI risk groups<hr></th> </tr> <tr> <th class="border-bottom">Low</th> <th class="border-bottom">Inter</th> <th class="border-bottom">High</th> <th class="border-bottom">Total</th> <th class="border-bottom">P value</th> </tr> </thead> <tbody> <tr> <td class="row-heading">RS risk groups</td> <td>Low</td> <td>283 (3.9%)</td> <td>85 (12.2%)</td> <td>20 (23.3%)</td> <td>388 (6.6%)</td> <td><0.001</td> </tr> <tr> <td class="row-heading"> </td> <td>Inter</td> <td>95 (7.1%)</td> <td>49 (24.3%)</td> <td>34 (27.8%)</td> <td>178 (15.8%)</td> <td>0.003</td> </tr> <tr> <td class="row-heading"> </td> <td>High</td> <td>12 (10%)</td> <td>32 (25.4%)</td> <td>55 (31.5%)</td> <td>99 (26.9%)</td> <td>0.2 </td> </tr> <tr> <td class="row-heading"> </td> <td>Total</td> <td>390 (4.8%)</td> <td>166 (18.3%)</td> <td>109 (29.0%)</td> <td>665</td> <td> </td> </tr> <tr> <td class="row-heading"> </td> <td>P value</td> <td>0.4</td> <td>0.07</td> <td>0.6</td> <td> </td></tr></tbody></table> |
All times are GMT -7. The time now is 03:54 PM. |
Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2024, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007 - 2021