Phase II neoadjuvant trial evaluating trastuzumab deruxtecan with or without anastroz
 

https://ascopubs.org/doi/abs/10.1200...5_suppl.TPS603

TRIO-US B-12 TALENT: Phase II neoadjuvant trial evaluating trastuzumab deruxtecan with or without anastrozole for HER2-low, HR+ early stage breast cancer.


https://www.onclive.com/view/trastuz...-breast-cancer

Trastuzumab Deruxtecan, With or Without Endocrine Therapy, Shows Promising Responses in Operable HR+, HER2-Low Breast Cancer

"...Additionally, the study demonstrated that trastuzumab deruxtecan yielded dynamic changes in HER2 tissue expression; 48.6% of patients (n = 17) experienced a change in HER2 IHC expression after trastuzumab deruxtecan treatment. Among patients who experienced a change, 88.2% had a decrease in HER2 expression between baseline and surgery—this included a subset of patients with HER2 IHC-0 disease...."