here too ER+her2+bc is different-- benefit of herceptin vs local regional recurrence
 

greater for ER+ her2+ than ER- her2+ breast cancer



ABSTRACT: Hormone receptor status influences the locoregional benefit of trastuzumab in patients with nonmetastatic breast cancer
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Background: Previous studies have shown that hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status influence the outcome of locoregional treatments. However, the interrelationship of these factors with trastuzumab is unclear. In this study, the role of HR and HER2 status on the locoregional benefit of trastuzumab treatment was investigated in patients with nonmetastatic breast cancer.

Methods: Locoregional outcomes of 5683 women treated at The University of Texas MD Anderson Cancer Center from 2000 to 2008 for invasive breast cancer were analyzed using Kaplan-Meier and Cox regression methods to compare 6 subgroups: HR-positive (HR+)/HER2-negative (HER2-), HR-/HER2- (triple-negative), HR+/HER2+ with or without trastuzumab, and HR-/HER2+ with or without trastuzumab.

Results: Overall, locoregional recurrence (LRR) was 5% at 5 years among patients with HER2+ disease. Patients with HR+/HER2+ disease treated with trastuzumab had half the rate of LRR as patients who did not receive trastuzumab, whereas patients with HR-/HER2+ disease had similar rates of LRR regardless of trastuzumab treatment. On Cox regression analysis comparing LRR risk to the cohort with HR+/HER2- disease, only the HR+/HER2+ cohort treated with trastuzumab had similar LRR risk (hazard ratio = 1.24, 95% confidence interval = 0.56-2.73, P = .591). All other subgroups, including the HR+/HER2+ cohort who did not receive trastuzumab, had significantly worse outcomes. LRR risk was highest among patients with triple-negative disease (hazard ratio = 4.73, 95% confidence interval = 3.42-6.54, P < .001).

Conclusions: Among patients with HR+/HER2+ disease, treatment with trastuzumab reduces LRR risk to the more favorable outcome of patients with HR+/HER2- disease. In contrast, the increased LRR risk among patients with HR-/HER2+ disease remains despite treatment with trastuzumab. Additional locoregional strategies are needed in this subgroup of patients.

Re: here too ER+her2+bc is different-- benefit of herceptin vs local regional recurre
 

Aha! Thanks Lani for this info. Gives us HR+/Her2+ gals some + info today!

all the best
caya

Re: here too ER+her2+bc is different-- benefit of herceptin vs local regional recurre
 

Re: here too ER+her2+bc is different-- benefit of herceptin vs local regional recurre
 

Yes, thank you Lani! This gives me some comfort and hope :)

Re: here too ER+her2+bc is different-- benefit of herceptin vs local regional recurre
 

Another grateful triple pos here Lani!

Re: here too ER+her2+bc is different-- benefit of herceptin vs local regional recurre
 

Lani, if we ever meet, you will be getting a big bear hug. Just wanted to give you the heads up.
Thank you!

Re: here too ER+her2+bc is different-- benefit of herceptin vs local regional recurre
 

I never doubted.....ok, so I was getting a tad nervous. Hey, Lani, any new info. on the cross talk between Tamoxifen and Her2?

Re: here too ER+her2+bc is different-- benefit of herceptin vs local regional recurre
 

Thanks much for posting.
K