another modality for treating breast cancer liver mets
 

Radiother Oncol. 2011 Apr 15. [Epub ahead of print]
Treatment of hepatic metastases of breast cancer with CT-guided interstitial brachytherapy - A phase II-study.
Wieners G, Mohnike K, Peters N, Bischoff J, Kleine-Tebbe A, Seidensticker R, Seidensticker M, Gademann G, Wust P, Pech M, Ricke J.

Klinik für Radiologie und Nuklearmedizin, Otto-von-Guericke-University Magdeburg, Germany.
Abstract
PURPOSE: The aim of the study was the evaluation of feasibility, safety and effectiveness of interstitial brachytherapy for the treatment of hepatic metastases of breast cancer.

MATERIALS AND METHODS: Forty-one consecutive patients with 115 unresectable hepatic metastases of breast cancer were included in this phase-II-trial. They were treated in 69 interventions of CT-guided-interstitial-brachytherapy of the liver. Brachytherapy was applied as a single fraction high-dose-irradiation (15-25Gy (Gray)) using a (192)Ir-source of 10Ci. Nineteen patients presented systemically pretreated extrahepatic tumors. Primary endpoints were complications, local tumor control and progression-free survival.

RESULTS: The median tumor diameter was 4.6cm (1.5-11cm). The median irradiation time per intervention was 26.5min (range: 7-47min). The applied median minimal dose at the CTV (clinical target volume) margin was 18.5Gy (12-25Gy). In 69 interventions and during the postinterventional period, one major complication (symptomatic post-interventional bleeding) (1.5%) and six minor complications occurred (8.7%). The median follow-up time was 18months (range: 1-56). After 6, 12 and 18months, local tumor control was 97%, 93.5% and 93.5%, intra- and extrahepatic progression free survival was 53%, 40% and 27%, and overall survival was 97%, 79% and 60%, respectively.

CONCLUSION: CT-guided-brachytherapy is safe and effective for the treatment of liver metastases of breast cancer.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
PMID: 21497930

Re: another modality for treating breast cancer liver mets
 

Lani,
Thank you for sending another potential option for those of us with Liver Mets.

While I recently completed a liver resection (removed entire left lobe), it is good to know there are yet more options should another met pop back up.

Thanks again for all you do for us....Lori

Re: another modality for treating breast cancer liver mets
 

Lani,

Thanks for this post. It gives a lot of hope to bc survivors with liver mets, that more treatments are in the pipeline.

Joan

Re: another modality for treating breast cancer liver mets
 

Thank you so much

Re: another modality for treating breast cancer liver mets
 

Thanks Lani! Michka

Re: another modality for treating breast cancer liver mets
 

I assume this is for low number or solitary liver mets?