Endoxifen exhibits anti-tumor activity in Her2+, tamox resistant tumors in lab
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Re: Endoxifen exhibits anti-tumor activity in Her2+, tamox resistant tumors in lab
Quote:
Tamoxifen effectiveness is determined by ability of a body to turn it into/metabolize to endoxifen. It's a pro-drug for endoxifen. http://www.sciencedaily.com/releases...1211141838.htm So I guess this article is suggesting some of the acquired resistance to TAM is due to a change in the metabolism/transformation of TAM...as opposed to resistance to TAM as a drug. |
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