HER2 Support Group Forums

HER2 Support Group Forums (https://her2support.org/vbulletin/index.php)
-   Articles of Interest (https://her2support.org/vbulletin/forumdisplay.php?f=31)
-   -   Over come resistance to Neratinib with Affinitor. (https://her2support.org/vbulletin/showthread.php?t=68500)

Nguyen 01-30-2020 05:19 PM

Over come resistance to Neratinib with Affinitor.
 
Given that Neratinib has been out not that long ago, and already resistance to it has developed as in

Neratinib resistance and cross-resistance to other HER2-targeted drugs due to increased activity of metabolism enzyme cytochrome P4503A4.

https://www.ncbi.nlm.nih.gov/pubmed/28152547

The below news is welcome. Essentially Neratinib and Affinitor could overcome this resistance.

Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers

https://www.sciencedirect.com/scienc...835?via%3Dihub


All times are GMT -7. The time now is 02:37 PM.

Powered by vBulletin® Version 3.8.7
Copyright ©2000 - 2021, vBulletin Solutions, Inc.
Copyright HER2 Support Group 2007 - 2021