Anyone Heard Of: "REXIN-G"???
 

I had a parent who came into the local newspaper to have a story done for her son. He was on a clinical trial of Rexin-G and his tumors were improved by over 50%. They are trying to get this trial here on the east coast since the success rate is terrific. He had to stay on the west coast to participate in the study and mom said it was worth the fight.

This young adult lost his life to an infection in his lungs, not the cancer, ugghh!! But mom's plight is not over, she needs to give back to all whom cancer affects. There happenened to be a gentleman who has contacted his mom, he had to thank her for all of her work getting this study recognized. His tumors have shrunk by over 62% when nothing else was working in his case!!

This drug has been used in stage IV cancers and has proven effective in later stage breast cancers. Could this be the next new miracle drug for us all?? Been around since 2003.

Anyone hear of this Rexin-G??

Believe51

Gosh, Marie, I have never heard of it but it sounds wonderful. I hope others will know something. Bumping this up to the top.

Here is some inf about it

http://www.cancercompass.com/cancer-news/1,14204,00.htm

Thanks Lily for posting that - encouraging indeed. Too bad the article didn't talk more about what it IS exactly! But it's good to hear new approaches are still coming...

Lily, thanks for looking it up. Joan

Here's the info...
 

Interesting information - wish I better understood it. It's in my neck of the woods - Pasadena CA. Could they really be on to something?

http://www.epeiusbiotech.com

Rexin-G™

(Retroviral Expression Vectors Bearing Inhibitory Genes)

The leading product of Epeius is REXIN-G™, which combines Epeius proprietary targeted vector system with a proprietary mutant cell-cycle control gene (i.e. anti-cancer gene). When given by intravenous infusions, REXIN-G™ has been shown to eradicate remote metastatic cancers in mice and to arrest cancer growth with shrinkage and necrosis of solid tumors in humans - determined by CT Scan and MRI – without eliciting systemic side effects. REXIN-G™ has been approved by the Philippine BFAD for systemic use in a Phase I/II clinical trial for all metastatic cancers. In the United States, REXIN-G™ is approved by the FDA for use in a Phase I clinical trial for metastatic pancreatic cancer. An ophthalmic formulation utilizing a similar TDS targeted gene delivery system, designated HAZIN-G, is currently under consideration by the FDA, for use in a proposed Phase I clinical trial for the reduction of severe cases of corneal scarring.

Sounds too good to be true...
 

http://www.epeiusbiotech.com

I watched a couple of video's on this site. They are currently enrolling people. It seems too good to be true.
Why aren't more people talking about these people if this really works?

I think that nanoparticles is a good way to deliver....poison to the monster

Flori remenber Marie know somebody that already used this staff .....so maybe is good !!

This is a link to the Phase I/II clinical trial for Rexin-G in Breast Cancer.

http://clinicaltrials.gov/ct2/show/N...rexin-g&rank=4

Girls, girls, girls.....
 

You girls are the best. Like I said, this woman had a son who had pancreatic cancer which was unresponsive to other drugs, this was his last hope and he was beating it for a long while. She was so sweet as we stood crying and discussing her brave son.

I hope this is the next great clinical trial for us here suffering with breast cancer in the later stages AND for pancreatic cancer which is in dire need of new drugs!!

Thanks for the links my Sweetnesses, I love you all. May we all live to see THE CURE or something quite close to it! I will be watching this drug. I will update you when mom returns with more inspiration and hope; and literature!>>Believe51

Thanks Beleive51 for this very interesting posting! I had never heard of this before either.

I found that they are now combining it with a immune vaccine in a new trial:
"The tumours of patients treated with Rexin-G plus Reximmune-C appeared to have a greater degree of necrosis, haemorrhage and cystic formations than the tumours of patients given Rexin-G alone, Gordon et al reported. In one patient with widespread metastatic breast cancer, the biopsied tumour nodule showed complete necrosis with no residual tumour. "

http://www.drugresearcher.com/news/n...elivery-system

and

http://gicancers.asco.org/ASCO/Abstr...stractID=32208

Bump
 

Marie, A few weeks ago I called the drugmaker, Epieus Biotechnologies about their breast cancer trial of Rexin-G, but it's only taking in place at their location in California. But if they have good results, they'll probably open the trial up to other locations.

This is what I know about the trial. It is done in Santa Monica, Ca. They are currently recuiting for the trial. I believe it is a 50 minute infusion. Three weeks on and one off for 4 cycles. I guess they would do scans and go from there.

I have a relative looking into it. I'll let you know if I find out more.

Any further news on this promising treatment?

Just received:

Interim analysis of attached Phase I/II Study of Rexin-G for Breast
Cancer:

Analysis of "Treated" Patients: There were 6 evaluable patients. Five of
six evaluable patients had stable disease as their best objective
response by RECIST criteria at 4-6 weeks after treatment initiation.
Using the International PET criteria, 2/6 patients had a partial
response (PR) and 4/6 patients had SD. Taken together, all 6 evaluable
patients had a positive response by PET Criteria. Three patients had
surgical resection of their tumors after at least 4 cycles of Rexin-G.
Post surgical resection, one has no evidence of disease, and two have
stable residual disease. One patient continues on the 9th cycle of
Rexin-G, living now for 13 months after Rexin-G treatment initiation on
Aug. 18, 2007. Median progression-free survival by RECIST was 6 months,
and median over-all survival was >9.5 months.

If you are interested in participating in this study, please call Vickie
Chua, clinical trials coordinator, at 310-552-9999.


Erlinda M. Gordon, M.D.
Vice President, Operations and Medical Affairs
Epeius Biotechnologies Corporation
475 Huntington Drive
San Marino CA 91108
Tel: 626-441-6695; Fax: 626-441-6692

Not the best but..a discussion:
http://www.cancercompass.com/message...all,1192,2.htm

Epeius tells me rexinG has been used in the Phillipines for about 3 years. BFAD (FDA equivalent) approved two years ago. Apparently Asian Hospital in Manila is a place using it.
http://www.asianhospital.com/
There was a trial at Mayo Rochester. I would like to somehow contact a doctor at Asian hospital for at least anecdotal results. Anyone in this forum live near or have contacts in Manila?

Anyone considering the trial? Unless I'm missing something, seems like a very impressive therapy. Maybe the most promising new therapy for failure by standard chemo??? New..although it may have been used in Manila for some time.

A thread regarding Rexin-G and pancreatic cancer. Interesting info on attempt to get it. Might be old information...one would hope.

http://www.cancercompass.com/message...ll,11022,0.htm