Go to Lily's site. There is a post that gives information about the trial. I am on phase 1, but there are more places that are offering the phase 2 trial.
Good luck,
Barbara

linda.. call asap.. dont let it progress one more day..

http://clinicaltrialsfeeds.org/clini...ow/NCT00509769

they are running the every 3 week trial in louisville..

Kentuckiana Cancer Institute
4500 churchman rd
Louisville Kentucky 40202 United States
Kentuckiana Cancer Institute

Map

(502) 368-0345

wrong zip.. 40215
run to live

better link

United States, KentuckyKentuckiana Cancer Institute Recruiting Louisville, Kentucky, United States, 40202 Contact: Leslie Haysley 502-561-8200 lhaysley@kci.us

http://www.clinicaltrials.gov/ct2/sh...ow_locs=Y#locn

barb,lily, marsha..

http://www.oncology-times.com/pt/pt-...-Jan102008.pdf

article by dr burris .. just scroll down.. about tras-dm1..

Thanks run to live, I appreciate the info and article and plan to talk about this with my onc. As part of the requirement it says no more than 3 different chemos. Does that mean 3 different chemo regimens ? The first regimen I had was taxotere and gemzar,and herceptin together. Does that count as 1 0r 2? thanks mykentuckyhome

You will have to speak with your oncologist about the chemo. I am not sure.
Barbara

that is one regimen.. but make the call.. dont delay.. dont give the cancer even one extra day inside your body...

Results
 

I received the results of my bone scan and CT scans. The scans indicated that the cancer in my bones is stable. Apparently, it takes a long time to get better results and even bones that have healed can be seen on these scans.
I feel well and feel pleased with these results.
Barbara H.

I'm glad for this news ...the same results for me ...stable is good news ( Kareng said, my Doctor said ,nurses said) so is good news ....

info on t-dm1 scientific stuff
 

mcc- dm1
 

I am seriously thinking of going on this trial. I got all the papers from louisville and Im going to talk to my onc on tues. I know that barb , marsha and lily are on this study, so the questions are directed to them. How long did it take between signing all the papers and your initial dose? I know there is a washout time of 2 weeks where you cant be on anything, and what kind of side effects have any of you had? They said I would be the first to go on this in kentucky so its kind of scary. Any input would be greatly appreciated.

ky home.. read some on my past postings and those of barb, lilly and marsha.... this trial is a godsend for her2 patients.. 3-4 yrs from now this drug will the the standard of care in breast cancer patients with her2 type cancer.

trastuzumab-dm1
 

http://www.cancernetwork.com/showArt...leID=180200338

a snippet

When the Herceptin antibody binds to a tumor cell expressing HER-2, the Herceptin/DM1 complex is internalized. The intracellular environment favors freeing of the DM1 from the antibody, makes the DM1 active, and kills the cell," Dr. Schwall said.
Three Breast Cancer Models
The conjugate was tested in three models. The first was a line of MCF7-HER2 human breast cancer cells engineered to express high levels of HER-2 and transplanted into nude mice. The conjugate caused complete tumor regression in all mice treated, while trastuzumab alone only slowed tumor growth. This experiment was repeated several times, with 9 to 10 mice per group. "With the conjugate, all of the tumors just disappeared," Dr. Schwall said.
The second model was nude mice transplanted with MDA-MB-361 breast tumor cells, which naturally express high levels of HER-2. As in the first experiment, the conjugate induced complete tumor regression in all 10 mice treated, while unconjugated trastuzumab only slowed tumor growth.
The third model was mammary tumors from MMTV-HER-2 transgenic mice transplanted into the mammary fat pads of 10 nontransgenic nude mice. The transplanted tumors grew aggressively and were allowed to reach 100 mm³ before treatment was initiated. "For reasons we don’t understand, Herceptin is not very effective against these tumors, even though they express high levels of HER-2," Dr. Schwall said.
When the mice were treated with the trastuzumab/DM1 conjugate, tumors regressed by more than 90% in all mice within 20 days. This effect was seen only in tumors overexpressing HER-2. "The tumors shrink and stay small for 60 to 70 days then start to grow back. When we treated them again, they responded again at similar levels," he said.
Maximal efficacy in this model was seen at a DM1 dose of 300 µg/kg, which corresponds to about 18 mg/kg of the conjugate, given once a week for 5 consecutive weeks. "These results show that Herceptin/DM1 has better activity than Herceptin alone in both Herceptin-responsive and Herceptin-resistant breast tumor models," Dr. Schwall said.

Well dang!!!!!

That's some pretty impressive stuff. I am so wanting to get into this trial, still waiting for it to open at UCSF tho.

and i have great olives..

the runts are always the best and most loveable, runt olive, and you are proof of the rule~

I got news today that the UCSF docs have been sent to Genentech, so it's just a matter of people taking care of business to get the trial underway there. I expect to be spending Monday enrolling and starting in the trial! Hoping this will be even better than flowers and chocolate...

good luck.. lets us all know when you begin..

I Maybe Entered Into The Trial With Trastuzumab-mcc-dm1- How Have You Done On This Trial? Anything I Should Know Before Deciding To Enter The Trial? I Had Bc Start In 1998 With Tumor On Right Breast-mastectomy And Reconst.stage 1 No Lymph Node Involvement--mets To Bone Since 2001 And Spot On Liver As Of 2007-just Now Using Faslodex And Herceptin Since End Of December 2007 And It Is Working So Far- My Onc Is Considering Placing Me On This Trial When The Faslodex Stops Working- Scans Scheduled For Next Week-if They Show Anything Has Worsened I Will Go Into The Trial Now. Ers

elle.. dont wait for the faslodex to stop working.. ask your oncologist to start now. prevention in your case IS THE CURE... which trial .. the weekly phase 1 or the every 3 week phase 2 trial.. i heard from a friend that the phase 1 trial will likely convert to phase 2 each week dosing possibly this summer.

regarding side effects.. pretty much the same as herceptin alone.. i have never been on it.. but i know many girls here on the forum are using it with great success..

we are still waiting for chrisy to update us on her treatment.... i think she has had her 2nd dose on the 3 week trial..

run to live.