Irene,

This is all way over my head. But I am glad that you and the rest of the crew, know all the right things to research. I, too, have always enjoyed your posts. When I look at your list of treatments, it is a wow. So keep up the good work and bring on the power.

Praying that you get into the trial.
Catherine

trial
 

HI Irene,
You are certainly in my thoughts. You are a fighter and I am sure you will find a way. Nevertheless, I hope, hope, hope, that you can find a way to be accepted into the Herceptin MCC-DM1 trial. It seems to be very effective for most patients, easy for most to tolerate, and it might work for you.
I would certainly fight for it.
Best wishes,
Barbara H.

Irene,

I can only echo what everyone else has said - you are an inspiration to so many. You have such a fighting spirit, I know it will continue to carry you through the rough times. I truly hope you can be enrolled in a trial and you will find the magic combo.

Stay strong and keep on fighting.

Irene,
Just wanted you to know you are in my prayers. Reading your Bio, you have been at this a long time and a great inspriation to us all to keep pressing forward. Peace be with you and may they find answers for you soon.

Irene in Tampa

You are in my thoughts and prayers and I hope you
get in the trial and get the drugs you need.
patb

My Dear Irene....
 

No...You are not crazy....you are Wise
 

Dear Irene,
NO you are not crazy....you are a strong wise women who knows how to place your options on the table and
fight back.

My heart breaks for you that you have to tell your family this news, but hopefully this week you will hear positive news to tag onto about your new treatment plan.

There are many new drugs to be considered/and/trials.
Please know you and your loved ones are in my prayers.

Sending you a huge healing hug,
Jean

Irene
 

Our hearts are heavy with your latest burden...you are much loved and much respected on this board. I can only reiterate what everyone else has said and that is that our collective thoughts, prayers, and strength go out to you.

HI Irene - take Lani's post to your doc - it should create a compelling conversation. I learned from some MDAnderson docs last November that they are starting to see that certain treatments in 'heavily pre-treated' patients might be actually changing the biology of the cancer, and I assume that that could maybe mean that it becomes sensitive to treatments that didn't seem to work before. Also, what about the Tykerb/Herceptin combination? Has you doc considered that one? Also, you and he should investigate whatever Dr. Kent Osborne is working on at the Baylor College of Medicine Breast Center in Houston. He is doing really interesting Her2 research and trials that he presented at SABCS in December. Have your doc put a call into him...

Irene-
I feel the same way - I HATE to tell my kids and family & friends bad news. For me once I have a plan it's easier to tell them what's going on. My disease is not yet under control and most days I just try to block what that really means from my life.

I don't have any chemo info to add - just wanted to say you are in my prayers. xxoo Flori

Irene

I'm sorry I can't help or advise you either but please know I'll be keeping you in my thoughts and praying you get into the trial.
Seems like you're due some good news soon on this!

Irene, As all of the others have said, you are the best among us and I am pulling for you, too. Want to meet you! Love, Ceesun

Irene,

All my love to you, I will be praying that a prompt suitable treatment is found for you. Dios te bendiga.

Paty

Irene,

Just wanted to let you know I am thinking of you, and praying the docs will find the magic chemo for you soon.

all the best
caya

Rechecking the cancer cells
 

Lani

I had a recheck of my cancer when I had my liver surgery back in 2005 which I requested to be sure nothing had changed in my HER2 status, and it was the same at that time. I will speak to my onc again and see what he thinks about rechecking again at this time.

I know they can get to my neck nodes pretty easily and we spoke about it earlier until my latest scan.

I am certainly heeding everyone's advise and checking everything out.

Has anyone heard / experienced this trio -

HERCEPTIN/ IRESSA/ PERTUZUMAB

I have not tried the Iressa or the Pertuzumab as yet. Maybe another option...

They still have not heard back about the DM1 trial and my insurance approve Cisplatin but is reviewing the Irinotecan which is another option. I am just not sure of this combo (what do I know huh) just a gut feeling.

I will keep on doing more homework and see what we decide on... I am getting fidgidy(?) since we have a long week-end and I have not been on any chemo for three weeks now.

Wishing everyone a wonder holiday weekend.

HERCEPTIN/ IRESSA/ PERTUZUMAB


this is the trial that Lani what post it many times ....with the mice's
I will love to try this combo ....

Yep, Irene, Iressa/Herceptin/Pertuzumab is the trial with the mice where the cancer went away and never came back...which Dr. Kent Osborne spoke of in San Antonio saying trials would be starting this year.
You should get your pathology checked again for ER/PR as well, as the rest of the "blockade" is to block ER.

I've been waiting for trials on this one for about 3 years now, it looks like they are finally getting close.

Also, the T-DM1 does have an exclusion for adriamycin above a certain amount, but you may not have had "excessive" adria and may still qualify.

Keep pushin, girl!

Irene - like Chrisy said, that is the combo that Dr. Kent Osborne and his colleagues have been working on. Here's his info:
http://www.breastcancercenter.net/faculty/osborne.htm

Here's the link to their clinical trials, and they have one for Herceptin/Tykerb too, it looks like...
http://www.breastcancercenter.net/cl...ials/index.htm

Dear Irene,
You are always in my prayers, all my love my sister!

Thinking of you Irene. Hoping you can find something to work. Bev