update I hate to give (with a little more positive spin)
 

Cure Liver Damage

I am beside myself. In googling for some hope for you, which
you must cling to
-- I found this link above.

It's my feeble attempt to offer you food for thought. And HOPE! You are a star. Your radiance and down to earth humor shine on us all, all the time. We're all so blessed to have you. And, we're not letting go so fast.

Your family is scared. That's what you're seeing. I have seen that fear in my husband and daughters. The love that spews up and out is palpable. Focus on the love, Chrisy. Show them what you're made of. Reach for anything you can to get you out of this mess!

I live in hope. You live in hope. Don't stop now. Hospice? I don't think so. It's too unfathomable for me to think. Not Chrisy. No way.

My heart is out of my body and with you in California, dear friend. OOOOOOOOOOOOOOOOOOO and my love, as always, and forever...
Andi

Re: update I hate to give (with a little more positive spin)
 

Chris, I am so saddened by your news, but awed by your grace and courage.
Thinking of you..... Pam

Re: update I hate to give (with a little more positive spin)
 

Oh, Chrisy..nooo. :( I am truly saddened to hear the words your doctor spoke to you. I can't pretend to know exactly how you feel, but I do know that leaving my family and seeing them suffer and hurt is the worst part of this whole damned thing. This just isn't fair, none of it is. I will send lots of prayers, and I still believe in miracles and hope you do too.

Re: update I hate to give (with a little more positive spin)
 

Chrisy, You are our standup, lie-down comic. You tell it like it is with wisdom, humor and honesty. No one would ever consider you a downer. You can sing off key if you want, but you are not closing down this bar. We will sing with you as you tell your liver to reboot. You are a doll and we all need you. Take good care of yourself and know that all of us are delighted to be your friend and allie. (sp)

Hugs,hope, prayers and miracles!

Re: update I hate to give (with a little more positive spin)
 

Re: update I hate to give (with a little more positive spin)
 

Christ,
I was praying the TACE procedure would work, I thought it was for the whole liver....Stay strong and fight....
With love,
Eileen

Re: update I hate to give (with a little more positive spin)
 

Chris,

Hand in there. Eribulin sounds like a winner ...

Am J Health Syst Pharm. 2012 May 1;69(9):745-55. doi: 10.2146/ajhp110237.
Eribulin mesylate: a novel halichondrin B analogue for the treatment of metastatic breast cancer.

McBride A, Butler SK.
Source

Arthur G. James Cancer Hospital, Richard J. Solove Research Institute, The Ohio State University, Columbus, 43212, USA. alimcbride@gmail.com

Abstract

PURPOSE:

The pharmacology, pharmacokinetics, clinical efficacy, safety, and administration of eribulin in patients with metastatic breast cancer are reviewed.
SUMMARY:

Classical chemotherapeutic agents for breast cancer have dominated treatment regimens even in the era of targeted therapy. Disease progression through these agents is often due to the development of resistance or lack of efficacy with these agents. Recently, a new nontaxane agent, eribulin mesylate, was approved for the treatment of metastatic breast cancer in patients who have received at least two prior chemotherapeutic agents.

Eribulin is a member of a new class of synthetic cytotoxic agents derived from the Japanese sea sponge Halichondria okadai. Eribulin differs from other antimicrotubule agents in that it can bind to the microtubule cap and inhibit tubulin polymerization, leading to microtubule arrest. In Phase II clinical trials, eribulin demonstrated activity in extensively pretreated patients who had previously received an anthracycline, taxane, and capecitabine and had shown disease progression within the last six months of treatment.

In a pivotal Phase III clinical trial of heavily pre-treated patients, patients who received eribulin versus the physician's treatment of choice showed a significant increase in overall and progression-free survival. Eribulin has a manageable adverse-effect profile, consisting mainly of neutropenia and fatigue. Eribulin has been associated with a low incidence of peripheral neuropathy.
CONCLUSION:

Eribulin, a novel synthetic antimicrotubule agent that binds to the vinca domain of tubulin and inhibits the polymerization of tubulin, offers a new treatment option for metastatic breast cancer or locally advanced breast cancer.

Re: update I hate to give (with a little more positive spin)
 

Dear Chris. I just can't find the words. It is a shock. I just don't want this to be happening to you. You opened the way for me with your TDM1 success. When my liver was stopping and was close to the end, I fought to find TDM1 beause your story, Chris, was hope for me. You always answered all my questions. And today I am alive and well. Oh, how I hope Eribulin will stop this progresion. Allow your liver to try TDM1 again, give you time. I hope you are not suffering although I can imagine how you feel in your body and in your head. I am sending strength, hope and love. Michka

Re: update I hate to give (with a little more positive spin)
 

Don't know what to say that hasn't already been said. I am so sad to read this news. You have always been one of the ppl who have been so inspiring and caring for others even when having a tough time yourself. I am praying for more time and a miracle!
Hugs
Ellie

Re: update I hate to give (with a little more positive spin)
 

Chrisy, I too was worried about not hearing an update from you, but you have again given a heartfelt post of your current place. I have always loved to read your posts and feel that you are connected to so many people here - you are a blessing. I really hope the eribulin works for you my friend......
Much love Marie x

Re: update I hate to give (with a little more positive spin)
 

I have no words, just prayers. You're one of my heroes.

- Penny

Re: update I hate to give (with a little more positive spin)
 

Chrisy, what a blessing you are! Praying for you

Re: update I hate to give (with a little more positive spin)
 

Crap, f'ing cancer.

Lots of brave and strong ladies on this board and you are right up there. Keep fighting

Janis

Re: update I hate to give (with a little more positive spin)
 

Chrisy,
I don't know what I'm talking about, but since you did so well on t-dm1, have been off the drug for some time, knowing so many things still aren't fully understood about cancer, I would question my onc before throwing in the towel, if kadcyla could be tried once more. One never knows.

Re: update I hate to give (with a little more positive spin)
 

Love, hugs, prayers and positive healing thoughts coming your way.

Re: update I hate to give (with a little more positive spin)
 

Chris,

Ditto to what others said above.

I agree that the toughest thing about this disease is knowing it, and my likely eventual demise from it, will cause others to suffer. I want so much to protect the people I love, and I can't.

Ultimately, all anyone can hope for is a life well lived. You, Chris, have achieved that. Your humor, compassion, dedication, loyalty, fierceness, and love shine through everything you write on this board. You set the standard for what it means to be a member of a support group.

I will never forget you. I will try, no matter what course my own cancer journey follows, to emulate your example and be a gift to others.

Your love is what will make it possible for those who love you to go on after you are no longer with them. The way you have lived your life is your legacy. You can rest assured that you have run the race extremely well.

Re: update I hate to give (with a little more positive spin)
 

I am so sorry to hear this news. I will join the others in prayer.
Leah

Re: update I hate to give (with a little more positive spin)
 

So sorry to hear about this dear Chrisy.
You have been such a Warrior Woman, fighter, esprit de coeur, you are AMAZING!
I am praying that the eribulin works, and add my thoughts that perhaps TDM1 can be given another chance.

Sending hugs and prayers from Canada, I'm sure PinkGirl will be doing the same.

all the best
caya

Re: update I hate to give (with a little more positive spin)
 

Chrisy,
Just wanted to say that I am thinking of you, praying for the new med to be the answer. You inspire me to fight this disease with your sage advice and whitty commentary. You are a survivor!
Sending hugs and healing vibes your way.
Pat

Re: update I hate to give (with a little more positive spin)
 

"acute liver failure" At least it's cute - gotta be easier than having ugly liver failure. Okay, I am grasping at hay straws, not liking this news at all, but respecting your courage in posting.

I have spent my life avoiding "good-byes" so I'll just say that if I hear a fat lady singing, I'll join in one chorus to show solidarity. In the meantime, I will pray for you to feel peace and continue to have strength. You show such grace and courage.

I have so much respect and admiration for you, and I am so sorry that you were given such bad news. Perhaps the Erube will give you some more time, without being too harsh - I certainly hope so. I am sure that you are surrounded by love, loving husband and loving family and friends. That is really what life comes down to - love. I have no words of wisdom, I feel heart broken that you are going thru this and I am grateful for our connection, our friendship and all your support over the years. My mom always said, "don't write the ending" so I'll keep that in mind and look forward to your updates as you're able...Sending much love, healing light, energy and wishes for a miracle. Flori