Re: My Sister Has Breast Cancer
 

Not what either of you wanted to hear. Oh why can't we identify the cause of this dreaded disease! Thank goodness she has your experience and words of comfort, hope and wisdom to help her. My best to you both! Hugs!

Re: My Sister Has Breast Cancer
 

Hi Sheila,

I meant to ask your sister's name.

I will definitely pray for you two.

Much Love to you Sheila,


Adriana

Re: My Sister Has Breast Cancer
 

You and your family are getting some challenges lately for sure. Aint that the way? Hang in there.

Re: My Sister Has Breast Cancer
 

Sheila,

Your sister is in my prayers. I'm very saddened to hear this news. Cancer doesn't seem to want to give us a break.

Joan

Re: My Sister Has Breast Cancer
 

Shelia,
I am so sorry your sister got this dreaded news. I can only imagine how hard this must be for the both of you. At least your sister has you to help her through this. But my heart goes out to you both. I will add your sister to my prayers, & that she gets through this quickly and becomes NED.

Chelee

Re: My Sister Has Breast Cancer
 

Any chance of her getting a sample for chemosensitivity testing from primary biopsy/surgery? That would seem prudent given the limited "proven" choices for triple neg.

Re: My Sister Has Breast Cancer
 

Mol Cancer. 2010 Oct 14;9:274.
Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells.

Li Y, Yuan YY, Meeran SM, Tollefsbol TO.

FREE TEXT

Source

Department of Biology, University of Alabama at Birmingham, 1300 University Boulevard Birmingham, AL 35294, USA.

Abstract

BACKGROUND:

The status of estrogen receptor-α (ERα) is critical to the clinical prognosis and therapeutic approach in breast cancer. ERα-negative breast cancer is clinically aggressive and has a poor prognosis because of the lack of hormone target-directed therapies. Previous studies have shown that epigenetic regulation plays a major role in ERα silencing in human breast cancer cells. Dietary green tea polyphenol, (-)-epigallocatechin-3-gallate (EGCG), is believed to be an anticancer agent in part through its regulation of epigenetic processes.
RESULTS:

In our current studies, we found that EGCG can reactivate ERα expression in ERα-negative MDA-MB-231 breast cancer cells. Combination studies using EGCG with the histone deacetylase (HDAC) inhibitor, trichostatin A (TSA), revealed a synergistic effect of reactivation of ERα expression in ERα-negative breast cancer cells. Reactivation of ERα expression by EGCG and TSA treatment was found to sensitize ERα-dependent cellular responses to activator 17β-estradiol (E2) and antagonist tamoxifen in ERα-negative breast cancer cells. We also found that EGCG can lead to remodeling of the chromatin structure of the ERα promoter by altering histone acetylation and methylation status thereby resulting in ERα reactivation. A decreased binding of the transcription repressor complex, Rb/p130-E2F4/5-HDAC1-SUV39H1-DNMT1, in the regulatory region of the ERα promoter also contributes to ERα transcriptional activation through treatment with EGCG and/or TSA.
CONCLUSIONS:

Collectively, these studies show that green tea EGCG can restore ERα expression by regulating epigenetic mechanisms, and this effect is enhanced when combined with an HDAC inhibitor. This study will facilitate more effective uses of combination approaches in breast cancer therapy and will help to explore more effective chemotherapeutic strategies toward hormone-resistant breast cancer.

PMID:20946668 [PubMed - indexed for MEDLINE]
PMCID: PMC2967543

Re: My Sister Has Breast Cancer
 

I am sending prayers and support your way for you and your sister. Enough is enough already with your family! There has to be some real good coming your way and soon. I have a friend who was diagnosed triple negative years ago and she was from Chicago but received a special treatment in Wisconsin and I believe it was Madison. She was diagnosed at least 10 years ago and is doing great. I pray the same for your sister.

Re: My Sister Has Breast Cancer
 

X@#%*****!!!!!!! #$%^^ @&*$@& #@$^&(@ !!!!!!!

Translation: damn, f'in disease! So sorry it has touched your family again, Sheila. Totally P.O.'d about this.

Bet she is as tough and wonderful as you! Love to both of you.

Re: My Sister Has Breast Cancer
 

Sheila,

Golly, gee. Would someone please step forward and turn off the cancer epidemic.....So sorry to hear about your sister. Gee, it does not seem fair that so many people have to go through this trauma. Hoping and praying for the right meds and the time it takes to get to the other side of treatment. Wishing you and your sister and your family all the best. Sending good vibes your way.

Catherine

Re: My Sister Has Breast Cancer
 

What did they come up with?

Re: My Sister Has Breast Cancer
 

Rich:
She met with the breast panel at Rush in Chicago...saw all the Dr's needed in one sitting. They ordered her tumor block for FISH testing, as they said it is extremely rare that she would be triple negative with papillary breast cancer and only the IHC was done. She had an MRI done on both breasts, and probable DCIS throughout showed up...not seen on the digital mammo or ultrasound. Timing is everthing when having an MRI and for the best read, needs to be done within certain days of the menstrual cycle. She has to meet with the plastic surgeon, as she is unsure if she wants reconstruction....then she is slated for CT's, Bone Scan, blood work and bilateral mastectomy mid July, and depending on findings and FISH results and node status, systemic treatment, AKA chemo will be added. She was very impressed with the team, and feels as she is in good hands. She seems better just knowing that she is now taking control.

Re: My Sister Has Breast Cancer
 

Seems like not much out there regarding neoadjuvant in triple neg. Of course, no treatment before surgery means chemosensitivity sample could be gathered;)
Saw this, and although from China, the figures are pretty surprising:
http://www.ncbi.nlm.nih.gov/pubmed/21528408

Re: My Sister Has Breast Cancer
 

Hang onto those slides..a new ER test may be worth checking out:
http://www.sciencedaily.com/releases...0627162825.htm

Re: My Sister Has Breast Cancer
 

Glad to hear she is in "fightin'" form like her big sis!

Re: My Sister Has Breast Cancer
 

Dear Sheila,
Have not been on the site much in the past few wks and just read your post about your sister. I am so sorry for her and you. I know you will be a wonderful supportive
sister and once treatment begins both of you will feel more in control.

Keeping both of you and your family in my prayers.
Hugs,
Jean

Re: My Sister Has Breast Cancer
 

Unique focus on trip neg:
http://www.yourhoustonnews.com/river...3ec039a91.html