Re: vaccine trial
Were you diagnosed as Stage III or Stage IV?
NCT00393783: Xenogeneic HER2/Neu DNA Immunization for Patients With Metastatic and High Risk Breast Cancer: A Phase I Study to Assess Safety and Immunogenicity Eligibility Criteria Breast cancer patients with AJCC Stage III or metastatic (AJCC Stage IV) disease that over-express HER2 will potentially be eligible for this trial. Patients may have measurable disease, evaluable disease or be without evidence of disease. They may be receiving hormonal therapy and they may have already received trastuzumab (Herceptin) or be receiving trastuzumab during this study. Inclusion Criteria: Patients must have ALL of the features listed below:
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Re: vaccine trial
NCT00195091
Phase II Study of Tetrathiomolybdate (TM) in Patients With Breast Cancer Eligibility Ages Eligible for Study: 18 Years and older Genders Eligible for Study: Female Accepts Healthy Volunteers: No Criteria Inclusion Criteria:
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Re: vaccine trial
NCT00195091
http://www.annieappleseedproject.org...06_8547904.gif Email from Advocate Amy B. October 2008: I would like to share this clinical trial with the advocate community and make sure that everyone who is eligible knows about the trial. Dr. Vahdat is my oncologist and I would encourage anyone interested to get in touch with her directly. I am including the general description of the trial and I am sure she will answer any specific questions. This is a general and very basic overview. A Phase II study of Tetrathiomolybdate (TM) in women with breast cancer at moderate to high risk of relapse. Linda Vahdat, MD NCI.gov clinical trials #:NCT00195091 Eligible patients: Patients with Stage 3 breast cancer or Stage 4 breast cancer with no evidence of disease who have completed what is considered standard therapy for their cancer. Hormonal treatments are allowed. Concurrent trastuzumab is not allowed. Trial: The goal of this clinical trial is to try to keep breast cancer cells in a dormant state by depleting copper, an essential component to helping them come out of dormancy. Background information: The observation that has always puzzled researchers is why a patient can relapse with cancer after many years of being cancer-free. Similarly, in patients whose cancer has spread, why can a treatment that removes all visible traces of breast cancer recur again? Multiple lines of evidence point to the fact that cancer cells lie dormant awaiting for a "signal" to start growing. It is believed that a crucial part of this "signal" is the ability to recruit blood vessels to the dormant tumor cell so that it can lay down blood vessels to feed itself and spread. This signal has been termed the "angiogenic switch". There are many compounds being tested that might affect the turning on of this "angiogenic switch". These are called anti-angiogenesis agents. It is well known that copper plays an essential role in the angiogenic process. People who have breast cancer tend to have higher copper levels than those who do not. We will be studying controlled copper depletion, a process where you lower the copper level in the body to the level where normal cellular processes can take place but tumor angiogenesis cannot. This process has been tried with patients with advanced cancer and the preliminary results support the hypothesis of this clinical trial. Practical information: This trial is being conducted at Weill Medical College of Cornell University by the Breast Cancer Research group. This trial consists of taking TM pills ( an anti-copper agent) for two years. For the first 6 weeks, one must visit our office once every 2 weeks for 3 visits. This is to make sure that the copper levels do not go too low. After that, a once a month visit is required. If you would like more information please contact: The office number until November 1: 212-746-7332 then 212-821-0644 Diana Donovan, ANP: donovdi@med.cornell.edu Marta Cobham, RN (research nurse): mac2034@med.cornell.edu Linda Vahdat, MD: ltv2001@med.cornell.edu This trial is supported by the Susan B Komen for the Cure, Breast Cancer Alliance of Greenwich and the NY Community Trust. Remember we are NOT Doctors and have NO medical training. |
Re: vaccine trial
'lizbeth you know me too well! Even though it is still summer, we (ha, that should read I) have already started gibbing weekly to get blooms for the October and November shows. We have already been invited to judge four shows and they expect blooms from us.
You know these vaccine trials are near and dear to my heart. If anything can get my attention, these can. I do go down to Mayo the 22nd for my next check up with scans etc. If I get a clean bill, it will be FIVE years. That is really hard to believe. I will let everyone know if I reach that mark! Lots of love, Sandra |
Re: vaccine trial
I know nothing about gibbing.
Can you believe 5 years? I'm hitting 6 years at Thanksgiving. That annoys me that a nurse would state something in an ongoing clinical trial is "not effective". That is seriously defeating the purpose of a blinded study. I love the one vaccine trial said that robust responders have experienced a zero recurrence rate. I had a huge local response. So am hoping the zero recurrence rate is a long term trend in all the vaccine trials. Stay well, and happy gibbing. |
Re: vaccine trial
Denise -
Dr. C was my surgeon at Penn. His study was only for early stage BC so I didn't qualify. I'm not sure if they're still enrolling or not. Denise |
Re: vaccine trial
Denise,
I was talking to a women from Pennies for action and she was thinking I would qualify, I'm 3C. I was wonder why it wasn't sponsored by the NIH. I'm so hoping I'm a canidate for this one since I wasn't able to join the vaccine trial at Walter Reed. I'm only about 2 hours from Philly. Looks like I might qualify for the one in New York but it's phase 1 and 5 1/2 hours away, not sure how I could work that around my work schedule. Hope your doing well Denise, I always read your posts and keep you in my prayers. Kind regards, Denise |
Re: vaccine trial
Hi
Dr C is the one who told me I didn't qualify as a 3c lady myself. If you find out that things have changed... would you please let me know. A vaccine trial... that close to home... would be a dream come true! Be well, name twin! And, thanks so much for the prayers! :) Denise |
Re: vaccine trial
Denise,
You may want to look into NCT00393783. It's in phase 1 and for stage III & IV. It's in New York. I have an appointment on Sept. 18th and plan to take the train in to the city. It makes me a little nervous that it is only in phase 1, but it looks promising. After talking with them it looks like I only have to go on weeks 1, 4,7 and 13, so I should be able to do schedule this around work. Denise |
Re: vaccine trial
Hey!
Thanks for the heads-up! I read over the criteria, and it seems that until I'm off steroids, Avastin, and Lapatnib... I can't do this one. But I hope it works out for you! Denise |
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