LIG1 loss reveals new treatment strategy for aggressive breast cancer

[News]

Loss of one copy of the DNA Ligase I (LIG1) gene in triple-negative breast cancers (TNBC) with TP53 mutations confers resistance to chemotherapy, but researchers at Baylor College of Medicine and collaborating institutions have identified a vulnerability in these cells and used it to their advantage.

More... (https://www.news-medical.net/news/20260716/LIG1-loss-reveals-new-treatment-strategy-for-aggressive-breast-cancer.aspx)