Gut microbes linked to fatty diet drive tumour growth

[Nguyen]

Gut microbes linked to fatty diet drive tumour growth

https://www.nature.com/articles/d41586-024-01443-4?utm_source=Live+Audience&utm_campaign=2c0ab5fd23-nature-briefing-weekly-20240517&utm_medium=email&utm_term=0_b27a691814-2c0ab5fd23-49230899

A high-fat diet promotes cancer progression by inducing gut microbiota?mediated leucine production and PMN-MDSC differentiation

https://www.pnas.org/doi/10.1073/pnas.2306776121

[ladyronghang]

The studies show that it’s not just the fat itself, but how it changes your gut microbiota that can accelerate tumor growth. Basically, a high-fat diet alters the microbial balance in a way that ramps up leucine production, which then fuels a specific type of immune cell (PMN-MDSCs) that suppresses the body’s ability to fight off tumors