Mcl-1 inhibition blocks cell survival in ER+ breast cancers

[News]

While estrogen receptor - + breast cancers express high levels of three anti-apoptotic Bcl-2 family members, pharmacological inhibition of Bcl-2 and/or Bcl-xL fails to induce cell death in ER + breast cancer cell lines, due to rapid and robust Mcl-1 upregulation.

More... (https://www.news-medical.net/news/20191126/Mcl-1-inhibition-blocks-cell-survival-in-ER2b-breast-cancers.aspx)