Stage 4, need more options

[valleygirl]

Hello,

Currently on Herceptin and Perjeta and have progression in lungs. What are my options and side effects?

[Carol Ann]

Hi Valleygirl,

I am so sorry, I don't have any advice, but look up Mtngirl/Amy's posts ... she is a long term metster with lung mets.

Carol Ann

[annettchen]

I believe that by the book, TDM-1 is in order in such a case - it's second line when Herceptin / Perjeta fail you in the body (based on what my oncologist says - mind you, I'm in Canada, I believe it's the same in the US, though...).

[Juls]

Hi Valley girl.

I had progression (2 bone mets) when on H, P & Femara. I was taken off Perjeta (trial drug here in UK) and Femara. Started Xeloda & now on 5th cycle of it. So far no major side effects other than slightly tired. Would this be an option?

[KatherineM]

valley girl - this just happened to me. i have lung mets and taxol and h and p stopped working. i've been on kadcyla (tdm-1) for three cycles now. they'll scan me in may to see if it's doing anything. i had very low platelet counts after cycle one and had to have a transfusion, have a cough and am a little short of breath, but otherwise tolerating it pretty well.

I'd definitely talk to your onc about kadcyla.

[Bunty]

Sorry to hear this Valley Girl,
I've had a long history of lung mets now for 8.5 years. Originally 3 2.5cm ones. After 6 months of Taxol, two disappeared, and one reduced to around 10mm. That one has grown and declined over the years. Abraxane was effective too - I had two different rounds of that. And then at the end of last year it started to grow again, so I had SBRT (Stereotactic Body Radiation Therapy - targeted 4-d radiation), and it seems to have hit it hard.

Good luck with your decision. I do hear that Kadcyla works well on lung mets.

Marie x

[Mtngrl]

I'd back up what the others have said. You have lots of options.

I've been (slowly) toggling back and forth between Herceptin and Perjeta alone and H&P with a chemo. Did Xeloda for awhile. Then did Abraxane. Now back to just H&P.

Everybody's different. Every cancer is different. Keep trying stuff until something clicks.