Navelbine & Herceptin Not Working

[KDR]

Since the surgery disaster, nothing but a downward slope. Navelbine and Herceptin not working. Scanning today and Saturday. Will keep you posted. Suggestions welcome.
Forward!

Karen

[Carol Ann]

Hi Karen,

No suggestions but just wanted you to know you are in my thoughts and prayers.

Carol Ann

[Coux92]

Oh Crud! so sorry, praying you find your magic potion!

[KDR]

An author friend once told me, "No matter what, everything will be o.k." And it will.

Will keep you posted. Waiting on scans.

Karen

[StephN]

Tumor markers or something in bloodwork that pointed to this?

Now I will send even stronger positive messages your way!

[k1982]

Sending you positive thoughts. God bless.

[Kkmom]

Karen, (http://her2support.org/vbulletin/showthread.php?t=58103)
Did you read this post about 3 down from yours. Cancer secret to success?! Finding your match! (http://her2support.org/vbulletin/showthread.php?t=58103) (http://her2support.org/vbulletin/images/misc/multipage.gif 1 (http://her2support.org/vbulletin/showthread.php?t=58103) 2 (http://her2support.org/vbulletin/showthread.php?t=58103&page=2) 3 (http://her2support.org/vbulletin/showthread.php?t=58103&page=3))

Praying for you - Pam

[Pamelamary]

Dear Karen - all digits crossed for you!
Sending love and positive vibes your way... Pam

[Redwolf8812]

prayers

:-) Penny

[suzan w]

Waiting is the pits. Sending a big hug your way.

[DizzyDo]

Sending prayers your way to find the next plan. You are so strong!

[Catherine]

Hi Karen,

Sending all the love and positive vibes I can. We are all here with you as you wait for the scan news. Prayers are coming your way!

[sassy]

Sending positive and healing thoughts and prayers.

[caya]

Prayers for you Karen from the Great White North.

all the best
caya

[MaineRottweilers]

Always, in my prayers.

[Pray]

Hoping and praying for you all goes well. Gods blessings.

[JennyB]

Best of luck with your next direction x

[michka]

Dear Karen, I hope the scans will be better than what you think and that your oncs will open new options. I keep my fingers crossed and watch for your next post. You are in my thoughts. Hugs. Michka

[KDR]

Thanks for all your messages of support and care! So far, the brain MRI is clean, waiting on PET results.
Interviewed IR at Weill Cornell today and really like him if onco agrees I am a candidate for Y90, along with a treatment of our choosing.
Karen

[mamacze]

Hi Angel - Feel the love….just feel that love flowing toward you from your Her2 sisters! I am SICK in my gut that you have to slog through more scans…another treatment - but always so happy to see love and support holding you up when you hit a bump in the road. Add my love to the river.
It seems like you have already taken the bull by the horns and found another trial - Y90 is getting some great reviews. Please let us know what your oncologist thinks.
(Amazing that we live in a place with immediate access to the most recently researched and approved drugs!)
XO

[Jackie07]

Karen,

Y-90 looks really good. I'm sending you good vibes.

Ann Surg Oncol. (http://www.ncbi.nlm.nih.gov/pubmed/24337647#) 2014 Apr;21(4):1296-303. doi: 10.1245/s10434-013-3436-1. Epub 2013 Dec 15.
Yttrium-90 radioembolization for unresectable, chemoresistant breast cancer liver metastases: a large single-center experience of 40 patients.

Saxena A (http://www.ncbi.nlm.nih.gov/pubmed?term=Saxena%20A%5BAuthor%5D&cauthor=true&cauthor_uid=24337647)1, Kapoor J (http://www.ncbi.nlm.nih.gov/pubmed?term=Kapoor%20J%5BAuthor%5D&cauthor=true&cauthor_uid=24337647), Meteling B (http://www.ncbi.nlm.nih.gov/pubmed?term=Meteling%20B%5BAuthor%5D&cauthor=true&cauthor_uid=24337647), Morris DL (http://www.ncbi.nlm.nih.gov/pubmed?term=Morris%20DL%5BAuthor%5D&cauthor=true&cauthor_uid=24337647), Bester L (http://www.ncbi.nlm.nih.gov/pubmed?term=Bester%20L%5BAuthor%5D&cauthor=true&cauthor_uid=24337647).
Author information (http://www.ncbi.nlm.nih.gov/pubmed/24337647#)


1Department of Interventional Radiology, St Vincent's Hospital Sydney, Darlinghurst, NSW, Australia, akshat16187@gmail.com.


Abstract

INTRODUCTION:

There are a paucity of data on the treatment of unresectable, chemoresistant breast cancer liver metastases (BRCLM) with yttrium-90 (Y90) radioembolization.
METHODS:

Forty patients underwent resin-based Y90 radioembolization for unresectable, chemoresistant BRCLM between 2006 and 2012 in a single institution. All patients were followed up with imaging studies at regular intervals as clinically indicated until death. Radiologic response was evaluated with the Response Criteria in Solid Tumors criteria. Clinical toxicities were prospectively recorded as per the National Cancer Institute Common Toxicity Criteria. Survival was calculated by the Kaplan-Meier method and potential prognostic variables were identified on univariate and multivariate analysis.
RESULTS:

Follow-up was complete in all patients. The median follow-up was 11.2 (range 0.6-30.5) months and the median survival after Y90 radioembolization was 13.6 months, with a 24-month survival of 39 %. On imaging follow-up of 38 patients who survived beyond 1 month of treatment, a complete response (CR) to treatment was observed in two patients (5 %), partial response (PR) in 10 patients (26 %), stable disease (SD) in 15 patients (39 %), and progressive disease (PD) in 11 patients (29 %). Two factors were associated with an improved survival on multivariate analysis: CR/PR to treatment (vs. SD vs. PD; p < 0.001) and chemotherapy after radioembolization (vs. no chemotherapy; p = 0.004). Sixteen patients (40 %) developed clinical toxicity after treatment; all complications were minor grade I/II and resolved without active intervention.
CONCLUSION:

This study provides supportive evidence of the safety and efficacy on Y90 radioembolization for the treatment of unresectable, chemoresistant BRCLM. Further prospective investigation is required to assess the suitability of this treatment in this population.

[Lisalou]

Good luck with the new regime, sounds promising! Hope the PET looks good

[Adriana Mangus]

Dear Karen, I have been thinking about you, I told my daughter about how
extraordinary and fabulous person you are. She has seen your pictures on
Facebook and totally agrees with me about how beautiful you are.

Please keep us posted after Saturday's scans. In the meantime enjoy your
hubby and daughter - they are so precious!

Hang in there my lovely friend. Love you. Hugs and more hugs.

Adriana